Identification
- Summary
Protein C is a medication used to treat protein C deficiency leading to purpura fulminans or coumarin-induced skin necrosis.
- Brand Names
- Beriplex, Ceprotin, Kcentra, Octaplex
- Generic Name
- Protein C
- DrugBank Accession Number
- DB11312
- Background
Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the endothelial cell surface to Activated Protein C (APC). Once in its activated form, APC functions as a serine protease with potent anticoagulant effects, especially in the presence of its cofactor protein S. APC exerts its effect by inactivating essential components of the coagulation cascade (specifically factors V and VIII), which leads to a decrease in thrombin formation, and therefore a reduction in clot formation.
The Protein C pathway provides a natural mechanism for control of the coagulation system and prevention of excessive procoagulant responses to activating stimuli. A lack of protein C in the body would lead to unchecked coagulation activation, resulting in thrombin generation and intravascular clot formation.
Protein C is available in concentrated form as the product Ceprotin, which is indicated for use in pediatric and adult patients with severe congenital protein C deficiency for the prevention and treatment of venous thrombosis and purpura fulminans.
- Type
- Biotech
- Groups
- Approved
- Biologic Classification
- Protein Based Therapies
Blood factors - Protein Structure
- Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- autoprothrombin IIA
- blood coagulation factor XIV
- Human protein C
- Protein C (coagulation inhibitor)
- Protein C concentrate
- Protein C concentrate (human)
- Protein C concentrate human
- Protein C human
Pharmacology
- Indication
Protein C concentrate is indicated for pediatric and adult patients with severe congenital protein C deficiency for the prevention and treatment of venous thrombosis and purpura fulminans.2 It is also found as a component of some prothrombin complex concentrate (i.e. Factor IX Complex (Human)) formulations, such as Kcentra.3
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- Contraindications & Blackbox Warnings
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In clinical studies, the intravenous administration of Protein C Concentrate demonstrated a temporary increase, within approximately half an hour of administration, in plasma levels of APC. Replacement of protein C in protein C-deficient patients is expected to control or, if given prophylactically, to prevent thrombotic complications.2
- Mechanism of action
Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Also known as blood coagulation factor XIV, Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the endothelial cell surface to Activated Protein C (APC). Once in its activated form, APC functions as a serine protease with potent anticoagulant effects, especially in the presence of its cofactor protein S. APC exerts its effect by inactivating essential components of the coagulation cascade (specifically factors V and VIII), which leads to a decrease in thrombin formation, and therefore a reduction in clot formation.
Target Actions Organism ACoagulation factor V inactivatorHumans ACoagulation factor VIII inactivatorHumans - Absorption
Cmax = 110 IU/dL Tmax = 0.50 hr
- Volume of distribution
Volume of distribution at steady state = 0.74 dL/kg
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Initial half life = 7.8 hr Terminal half life = 9.9 hr
- Clearance
CL = 0.0533 dL/kg/h
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The risk or severity of bleeding can be increased when Abciximab is combined with Protein C. Aceclofenac The risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Protein C. Acemetacin The risk or severity of bleeding and hemorrhage can be increased when Protein C is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding can be increased when Acenocoumarol is combined with Protein C. Acetylsalicylic acid Acetylsalicylic acid may increase the anticoagulant activities of Protein C. Albutrepenonacog alfa The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Protein C. Alclofenac The risk or severity of bleeding and hemorrhage can be increased when Alclofenac is combined with Protein C. Aldesleukin The risk or severity of bleeding can be increased when Protein C is combined with Aldesleukin. Alemtuzumab The risk or severity of bleeding can be increased when Protein C is combined with Alemtuzumab. Alteplase The risk or severity of bleeding can be increased when Alteplase is combined with Protein C. 
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- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
Products
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Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Ceprotin Kit 1000 [iU]/10mL Intravenous Baxalta US Inc. 2010-08-09 Not applicable US 
Ceprotin Injection, powder, for solution 1000 IU Intravenous Takeda Manufacturing Austria Ag 2016-09-08 Not applicable EU 
Ceprotin Kit 500 [iU]/5mL Intravenous Baxalta US Inc. 2010-08-09 Not applicable US Ceprotin Injection, powder, for solution 500 IU Intravenous Takeda Manufacturing Austria Ag 2016-09-08 Not applicable EU Ceprotin Kit 100 [iU]/1mL Intravenous Baxalta Us Inc 2010-08-09 2018-11-30 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Beriplex P/n 1000 Protein C (1640 unit) + Coagulation Factor IX Human (1240 unit) + Coagulation factor VII human (1000 unit) + Coagulation factor X human (2040 unit) + Protein S human (1360 unit) + Prothrombin (1600 unit) Powder, for solution Intravenous Csl Behring 2013-11-21 Not applicable Canada 
Beriplex P/N 1000 I.E. Pulver und Lösungsmittel zur Herstellung einer Injektionslösung Protein C (1200 I.E.) + Coagulation Factor IX Human (1020 IE) + Coagulation factor VII human (700 IE) + Coagulation factor X human (1640 IE) + Protein S human (1000 IE) + Prothrombin (1360 IE) Injection, powder, for solution Parenteral Csl Behring 2013-04-16 Not applicable Austria 
Beriplex P/N 250 I.E. Pulver und Lösungsmittel zur Herstellung einer Injektionslösung Protein C (300 IE) + Coagulation Factor IX Human (255 IE) + Coagulation factor VII human (175 IE) + Coagulation factor X human (410 IE) + Protein S human (250 IE) + Prothrombin (340 I.E.) Injection, powder, for solution Parenteral Csl Behring 2008-02-27 Not applicable Austria Beriplex P/n 500 Protein C (820 unit) + Coagulation Factor IX Human (620 unit) + Coagulation factor VII human (500 unit) + Coagulation factor X human (1020 unit) + Protein S human (680 unit) + Prothrombin (800 unit) Powder, for solution Intravenous Csl Behring 2011-07-28 Not applicable Canada Beriplex P/N 500 I.E. Pulver und Lösungsmittel zur Herstellung einer Injektionslösung Protein C (600 I.E.) + Coagulation Factor IX Human (510 IE) + Coagulation factor VII human (350 IE) + Coagulation factor X human (820 IE) + Protein S human (500 IE) + Prothrombin (680 IE) Injection, powder, for solution Parenteral Csl Behring 2008-02-27 Not applicable Austria COFACT 250 IU/10 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADET Protein C (250 IU) + Coagulation Factor IX Human (250 IU) + Coagulation factor VII human (135 IU) + Coagulation factor X human (245 IU) + Protein S human (45 IU) + Prothrombin (245 IU) Injection Intravenous CENTURION İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey 
COFACT 500 IU/20 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADET Protein C (500 IU) + Coagulation Factor IX Human (500 IU) + Coagulation factor VII human (270 IU) + Coagulation factor X human (490 IU) + Protein S human (90 IU) + Prothrombin (490 IU) Injection Intravenous CENTURION İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey Kcentra Protein C (1240 U/40mL) + Coagulation Factor IX Human (1020 U/40mL) + Coagulation factor VII human (700 U/40mL) + Coagulation factor X human (1520 U/40mL) + Protein S human (920 U/40mL) + Prothrombin (1180 U/40mL) Kit Intravenous CSL Behring GmbH 2013-12-13 Not applicable US Kcentra Protein C (620 U/20mL) + Coagulation Factor IX Human (510 U/20mL) + Coagulation factor VII human (350 U/20mL) + Coagulation factor X human (760 U/20mL) + Protein S human (460 U/20mL) + Prothrombin (590 U/20mL) Kit Intravenous CSL Behring GmbH 2013-04-29 Not applicable US Octaplex Protein C (1240 unit / vial) + Coagulation Factor IX Human (1000 unit / vial) + Coagulation factor VII human (960 unit / vial) + Coagulation factor X human (1200 unit / vial) + Protein S human (1280 unit / vial) + Prothrombin (1520 unit / vial) Kit; Powder, for solution Intravenous Octapharma Pharmazeutika Produktionsges M B H 2015-08-11 Not applicable Canada
Categories
- ATC Codes
- B01AD12 — Protein c
- Drug Categories
- Amino Acids, Peptides, and Proteins
- Anticoagulants
- Biological Factors
- Blood and Blood Forming Organs
- Blood Coagulation Factor Inhibitors
- Blood Proteins
- Cardiovascular Agents
- Decreased Coagulation Factor Activity
- Enzyme Precursors
- Enzymes
- Enzymes and Coenzymes
- Fibrin Modulating Agents
- Fibrinolytic Agents
- Glycoconjugates
- Glycoproteins
- Hematologic Agents
- Protein Precursors
- Proteins
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- Y2RU654EXB
- CAS number
- Not Available
References
- General References
- Esmon CT, Vigano-D'Angelo S, D'Angelo A, Comp PC: Anticoagulation proteins C and S. Adv Exp Med Biol. 1987;214:47-54. [Article]
- FDA Approved Drug Products: Ceprotin (protein C concentration [human]) powder for solution [Link]
- FDA Approved Drug Products: KCENTRA (Prothrombin Complex Concentrate (Human)) For Intravenous Use, Lyophilized Powder for Reconstitution [Link]
- External Links
- KEGG Drug
- D08796
- PubChem Substance
- 347911185
- 723868
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Protein_C
- FDA label
- Download (674 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Bleeding / Blood Loss During Surgery / Cardiovascular Surgical Procedures / Fresh Frozen Plasma / Prothrombin Complex Concentrates 1 4 Recruiting Treatment Coagulation Disorder / Massive Hemorrhage / Traumatic haemorrhage 1 4 Withdrawn Treatment Postpartum Haemorrhage (PPH) 1 3 Completed Treatment Acute Major Bleeding / Coagulation Disorder 1 3 Completed Treatment High Bleeding Risk 1 3 Completed Treatment Reversal of Anticoagulant Treatment 1 3 Completed Treatment Reversal of Coagulopathy 1 3 Not Yet Recruiting Treatment Ischemic Stroke 1 3 Not Yet Recruiting Treatment Traumatic Injuries 1 3 Recruiting Treatment Acute Major Bleeding 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Powder, for solution Intravenous Injection, powder, for solution Parenteral Injection, powder, for solution Intravenous Injection, powder, for solution Intravenous 1000 IU Injection, powder, for solution Intravenous 500 IU Injection, powder, for solution Intravenous; Subcutaneous 1000 IU Injection, powder, for solution Intravenous; Subcutaneous 500 IU Kit Intravenous 100 [iU]/1mL Kit Intravenous 1000 [iU]/10mL Kit Intravenous 500 [iU]/5mL Injection, solution Intravenous 500 iu Injection Intravenous Kit Intravenous Kit; powder, for solution Intravenous Injection, powder, for solution Intravenous drip 520 IU/vial - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inactivator
- General Function
- Copper ion binding
- Specific Function
- Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
- Gene Name
- F5
- Uniprot ID
- P12259
- Uniprot Name
- Coagulation factor V
- Molecular Weight
- 251701.245 Da
References
- FDA Approved Drug Products: Ceprotin (protein C concentration [human]) powder for solution [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inactivator
- General Function
- Oxidoreductase activity
- Specific Function
- Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
- Gene Name
- F8
- Uniprot ID
- P00451
- Uniprot Name
- Coagulation factor VIII
- Molecular Weight
- 267007.42 Da
References
- FDA Approved Drug Products: Ceprotin (protein C concentration [human]) powder for solution [Link]
Drug created at December 03, 2015 16:52 / Updated at July 11, 2020 03:43