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Displaying results 1071 - 1080 of 10000 in total
  1. Drug

    Amisulpride

    go.drugbank.com/drugs/DB06288
    ApprovedInvestigational

    Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. … In the US, the intravenous formulation of amisulpride is used to treat and prevent postoperative nausea and vomiting in adults, either as monotherapy or in combination with another antiemetic agent of

    Synonyms: 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide, 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamideCategories: Benzamides and benzamide derivatives
  2. Drug

    Octreotide

    go.drugbank.com/drugs/DB00104
    ApprovedInvestigational

    Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. … This drug was developed by Chiasma Inc.[L14495,L14507,L14528]

    Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsProducts: SANDOSTATIN LAR 20MG, SANDOSTATIN LAR 10MG
  3. Drug

    Methadone

    go.drugbank.com/drugs/DB00333
    ApprovedInvestigational

    Use of OAT is also intended to lead to social stabilization by reducing crime rates, incarceration, use of illicit opioids such as [heroin] or [fentanyl], and ultimately marginalization. … [A497,A5344] Specifically by inhibiting the NMDA receptor, methadone dampens a major excitatory pain pathway within the central nervous system.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: Alphadone Syrup 10mg/ml, METADONA SOLUCIÓN ORAL 10MG/ML
  4. Target

    B- and T-lymphocyte attenuator

    go.drugbank.com/bio_entities/BE0010629
    TargetHumans

    Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). … In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.

    Polypeptides: B- and T-lymphocyte attenuatorSynonyms: B- and T-lymphocyte-associated protein
  5. Drug

    Ritonavir

    go.drugbank.com/drugs/DB00503
    ApprovedInvestigational

    It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. … Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors

    Mixtures: Kaletra Tablet 100mg/25mg, Kaletra 100mg/25mg Film-Coated TabletCategories: lopinavir and ritonavir, darunavir and ritonavir
  6. Drug

    Saxagliptin

    go.drugbank.com/drugs/DB06335
    ApprovedInvestigational

    Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.

    Mixtures: Saxagliptin and Metformin, Saxagliptin and MetforminCategories: Alimentary Tract and Metabolism, metformin and saxagliptin
  7. Drug

    Cisplatin

    go.drugbank.com/drugs/DB00515
    ApprovedInvestigational

    It was the first member of its class, which now also includes carboplatin and oxaliplatin. … cancer, and ovarian cancer), lymphomas and germ cell tumors.

    Categories: Indicators and Reagents, Antineoplastic and Immunomodulating AgentsProducts: NOVELDEXIS® 10MG, Cisplatin Inj 1mg/ml
  8. Drug

    Ceritinib

    go.drugbank.com/drugs/DB09063
    ApprovedInvestigational

    Ceritinib exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells … results in constitutive kinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype.

    Categories: Antineoplastic and Immunomodulating AgentsSynonyms: N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propane-2-sulfonamide
  9. Drug

    Racephedrine

    go.drugbank.com/drugs/DB14752
    Approved

    Categories: Herbs and Natural Products, Alpha-and Beta-adrenergic AgonistsProducts: Fyto-HB Tea - 10mg/pck, Zand Decongestant Herbal Cap
  10. Drug

    Nilutamide

    go.drugbank.com/drugs/DB00665
    ApprovedInvestigational

    Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). … Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.

    Categories: Antineoplastic and Immunomodulating Agents, Hormone Antagonists and Related AgentsProducts: Anandron Tab 100mg, Anandron - Tab 100mg