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Displaying results 101 - 110 of 1809 in total
  1. Drug

    Recombinant human alkaline phosphatase

    go.drugbank.com/drugs/DB17672
    Investigational

    Synonyms: recAP
  2. Pathway

    Histamine H1 Receptor Activation

    smpdb.ca/view/SMP0063452
    Signaling

    This results in the dissociation of a Gαq-GTP monomer and a Gβγ dimer from the receptor . … Upon binding by histamine, the H1 receptor allosterically activates the G-protein by exchanging GDP for GTP at the G-protein's alpha subunit (Gαq).

    Drugs: Calcium
    Enzymes: Histamine H1 receptor, Inositol 1,4,5-trisphosphate receptor type 1
  3. Drug

    Olinvacimab

    go.drugbank.com/drugs/DB16265
    Investigational

    Olinvacimab is under investigation in clinical trial NCT03033524 (Trial to Evaluate the Safety of Ttac-0001(tanibirumab) in Recurrent Glioblastoma).

    Synonyms: Fully human monoclonal antibody targets vascular endothelial growth factor receptor 2, Immunoglobulin g1, anti-(human vascular endothelial growth factor receptor 2) (human monoclonal ttac-0001 heavy chain), disulfide with human monoclonal ttac-0001 light chain, dimer
  4. Drug

    Boserolimab

    go.drugbank.com/drugs/DB17452
    Investigational

    Synonyms: Immunoglobulin G1-kappa, anti-(homo sapiens CD27 (TNFRSF7, tumor necrosis factor receptor (TNFR) superfamily member 7))
  5. Drug

    Vonlerolizumab

    go.drugbank.com/drugs/DB16352
    Investigational

    Vonlerolizumab is under investigation in clinical trial NCT03029832 (A Study of MOXR0916 in Combination With Atezolizumab Versus Atezolizumab Alone in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma Who Ar...

    Synonyms: Immunoglobulin g1-kappa, anti-(human tumor necrosis factor receptor superfamily member 4 (act35 antigen, ox40l receptor, cd134 antigen))humanized mouse monoclonal antibody: .gamma.1 heavy chain (1-447), Immunoglobulin g1-kappa, anti-(homo sapiens tnfrsf4(tumor necrosis factor receptor (tnfr) superfamily member 4, act35, ox40, cd134)), humanized monoclonal antibody
  6. Drug

    Dorzolamide

    go.drugbank.com/drugs/DB00869
    ApprovedInvestigational

    Dorzolamide is a non-bacteriostatic sulfonamide derivative [A1304] and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and

    Mixtures: DORZOCOMP VISI 20+5MG/ML, DORZOCOMP VISI 20+5MG/ML
  7. Drug

    Anvatabart opadotin

    go.drugbank.com/drugs/DB18290
    Investigational

    Synonyms: ; conjugated at two engineered sites via a stable, Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody
  8. Drug

    Anti-CD7 CAR T-cell therapy

    go.drugbank.com/drugs/DB18128
    Experimental

    Synonyms: A chimeric antigen receptor (CAR) immunotherapy directed against the target protein CD7
  9. Drug

    Talquetamab

    go.drugbank.com/drugs/DB16678
    ApprovedInvestigational

    Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. … [L47765] Talquetamab binds to GPRC5D, a cell surface receptor expressed predominantly on multiple myeloma cells, and CD3 on T cells.

    Synonyms: IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D)), AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL, IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D)), AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL
  10. Drug

    STM-217

    go.drugbank.com/drugs/DB17358
    Experimental

    Synonyms: Soluble receptor fused to part of an antibody that is designed to block the growth factor activin a