Sodium fluorophosphate

Identification

Name
Sodium fluorophosphate
Accession Number
DB09484
Description

Sodium monofluorophosphate is used in OTC dental preparations to help protect against cavities.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 143.949
Monoisotopic: 143.93644758
Chemical Formula
FNa2O3P
Synonyms
  • Disodium phosphorofluoridate
  • Phosphorofluoridic acid, disodium salt
  • Sodium monofluorophosphate

Pharmacology

Pharmacology
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Indication

Sodium monofluorophosphate is indicated for the treatment of cavities

Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity

LD50 Oral: rat-502 -638 mg/kg LC50 Inhalation: rat-male and female-4 h-> 2,1 mg/l

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium fluorophosphate.
AclidiniumThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Aclidinium.
AlfentanilThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Alfentanil.
AlloinThe risk or severity of adverse effects can be increased when Sodium fluorophosphate is combined with Alloin.
AlmasilateThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Almasilate.
Aluminium phosphateThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Aluminium phosphate.
Aluminum hydroxideThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Aluminum hydroxide.
AmantadineThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Amantadine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Sodium fluorophosphate.
AmiodaroneThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Amiodarone.
Interactions
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Food Interactions
No interactions found.

Products

Products
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Active Moieties
NameKindUNIICASInChI Key
Monofluorophosphate ionionic4964UZ79MI15181-43-8DWYMPOCYEZONEA-UHFFFAOYSA-L
Fluoride ionionicQ80VPU408O16984-48-8KRHYYFGTRYWZRS-UHFFFAOYSA-M
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
100 toothpast e MorningGel, dentifrice0.75 g/100gOralMGRU2020-12-01Not applicableUS flag
100 toothpast e NightGel, dentifrice0.75 g/100gOralMGRU2020-12-01Not applicableUS flag
10g Colgate plus Toothbrush KitKit7.6 mg/1gDentalColgate-Palmolive (Thailand) Limited - Branch2018-06-07Not applicableUS flag
10g Colgate plus Toothbrush plus Floss KitKit7.6 mg/1gDentalColgate-Palmolive (Thailand) Limited - Branch2018-06-07Not applicableUS flag
365 Everyday Value Cavity Fighting and WhiteningPaste, dentifrice0.76 g/100gDentalWhole Foods Market, Inc.2019-03-06Not applicableUS flag
365 Everyday Value Kids FlouridePaste, dentifrice0.76 g/100gDentalWhole Foods Market, Inc.2019-03-06Not applicableUS flag
5g Colgate plus Toothbrush KitKit7.6 mg/1gDentalColgate-Palmolive (Thailand) Limited - Branch2018-06-07Not applicableUS flag
5g Colgate plus Toothbrush plus Floss KitKit7.6 mg/1gDentalColgate-Palmolive (Thailand) Limited - Branch2018-06-07Not applicableUS flag
AdoptaPlatoonPaste0.76 g/100gDentalHUAIAN ZONGHENG BIO-TECH CO., LTD2016-07-10Not applicableUS flag
Advanced Fluoride AnticavityPaste, dentifrice0.76 g/100gDentalPersonal Care Products2011-01-24Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
28tak Clair ToothSodium fluorophosphate (0.13 g/60g) + Silicon dioxide (4.8 g/60g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUS flag
ATOMY PROPOLIS 200gSodium fluorophosphate (0.32 g/200g) + Sodium fluoride (0.20 g/200g)Paste, dentifriceOralAtomy Co., Ltd.2015-02-012017-12-01US flag
ATOMY PROPOLIS 50gSodium fluorophosphate (0.08 g/41) + Sodium fluoride (0.05 g/41)Paste, dentifriceOralAtomy Co., Ltd.2015-02-012017-12-01US flag
Atomy Propolis Toothpas Te 200gSodium fluorophosphate (0.32 g/200g) + Sodium fluoride (0.2 g/200g)Paste, dentifriceOralAtomy Co., Ltd.2019-11-25Not applicableUS flag
ATOMY PROPOLIS TOOTHPAS TE 200gSodium fluorophosphate (0.32 g/200g) + Sodium fluoride (0.20 g/200g)Paste, dentifriceOralAtomy Co., Ltd.2016-08-012019-11-01US flag
ATOMY PROPOLIS TOOTHPAS TE 50gSodium fluorophosphate (0.08 g/50g) + Sodium fluoride (0.05 g/50g)Paste, dentifriceOralAtomy Co., Ltd.2016-08-012019-11-01US flag
Atomy Propolis Toothpas Te 50gSodium fluorophosphate (0.08 g/50g) + Sodium fluoride (0.05 g/50g)Paste, dentifriceOralAtomy Co., Ltd.2019-12-01Not applicableUS flag
Atomy ToothpasteSodium fluorophosphate (0.32 g/200g) + Sodium fluoride (0.2 g/200g)Paste, dentifriceDentalAtomy Co., Ltd.2010-05-25Not applicableUS flag
Baird Good NightSodium fluorophosphate (0.0976 g/100g) + Sodium fluoride (0.74 g/100g)Paste, dentifriceDentalJK INSPIR Co., Ltd2020-12-03Not applicableUS flag
BIOTENE SensitiveSodium fluorophosphate (1 mg/1g) + Potassium nitrate (19.3 mg/1g)PasteDentalGlaxo Smith Kline Consumer Heathcare Lp2011-04-152013-01-31US flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
28tak Clair ToothSodium fluorophosphate (0.13 g/60g) + Silicon dioxide (4.8 g/60g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUS flag
Black Is WhiteSodium fluorophosphate (.095 mg/1mg)Gel, dentifriceDentalCuraden Ag2017-01-292020-01-13US flag
Chunzam Silk Amino Acid ToothSodium fluorophosphate (0.33 g/100g) + Silicon dioxide (4 g/100g) + alpha-Tocopherol acetate (0.1 g/100g)Paste, dentifriceDentalChunzam Bio Co Ltd2016-11-11Not applicableUS flag
Colgate Cavity Protection Great Regular FlavorSodium fluorophosphate (11.4 mg/1g)PasteDentalColgate Oral Pharmaceuticals, Inc.2012-02-032019-08-01US flag
Dr.EL BERRYGOOD TOOTHSodium fluorophosphate (0.38 g/100g) + Silicic acid (10 g/100g) + Silicon dioxide (5 g/100g) + alpha-Tocopherol acetate (0.09 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-01Not applicableUS flag
Dr.EL CHARCOR PARTY TOOTHSodium fluorophosphate (0.38 g/100g) + Silicic acid (10 g/100g) + Silicon dioxide (5 g/100g) + alpha-Tocopherol acetate (0.09 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-01Not applicableUS flag
Dr.EL CLAIR TOOTHSodium fluorophosphate (0.22 g/100g) + Silicon dioxide (8 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-01Not applicableUS flag
Dr.EL ORTHO CARE TOOTHSodium fluorophosphate (0.5 g/100g) + Silicon dioxide (15 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-01Not applicableUS flag
DR.EL Very Good ToothSodium fluorophosphate (0.38 g/100g) + Silicic acid (10 g/100g) + Silicon dioxide (5 g/100g) + alpha-Tocopherol acetate (0.09 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-012019-09-01US flag
Exoden CavitySodium fluorophosphate (0.76 g/100g) + Alcloxa (0.16 g/100g) + Silicon dioxide (15 g/100g)PasteTopicalLifeon Corp.2021-03-10Not applicableUS flag

Categories

ATC Codes
A12CD02 — Sodium monofluorophosphateA01AA02 — Sodium monofluorophosphate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkali metal phosphonates. These are inorganic compounds in which the largest oxoanion is phosphonate, and in which the heaviest atom not in an oxoanion is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal oxoanionic compounds
Sub Class
Alkali metal phosphonates
Direct Parent
Alkali metal phosphonates
Alternative Parents
Inorganic sodium salts / Inorganic oxides
Substituents
Alkali metal phosphonate / Inorganic oxide / Inorganic salt / Inorganic sodium salt
Molecular Framework
Not Available
External Descriptors
inorganic sodium salt, inorganic phosphate (CHEBI:86431)

Chemical Identifiers

UNII
C810JCZ56Q
CAS number
10163-15-2
InChI Key
BFDWBSRJQZPEEB-UHFFFAOYSA-L
InChI
InChI=1S/FH2O3P.2Na/c1-5(2,3)4;;/h(H2,2,3,4);;/q;2*+1/p-2
IUPAC Name
disodium phosphorofluoridate
SMILES
[Na+].[Na+].[O-]P([O-])(F)=O

References

General References
  1. Safety Data Sheet [Link]
  2. Drug information [Link]
KEGG Drug
D05864
PubChem Substance
347910454
ChemSpider
22686
RxNav
56501
ChEBI
86431
ChEMBL
CHEMBL1908359
Wikipedia
Sodium_monofluorophosphate
AHFS Codes
  • 34:00.00 — Dental Agents

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionDental Prophylaxis and Implant Surgery1
4CompletedTreatmentGingivitis2
4CompletedTreatmentNeoplasms, Head and Neck1
4WithdrawnTreatmentCompliance / Dry Mouth / Urinary Bladder, Overactive1
3CompletedTreatmentCaries1
3CompletedTreatmentDentin Sensitivity1
3CompletedTreatmentDentine Hypersensitivity5
3CompletedTreatmentGingival Diseases1
3CompletedTreatmentGingivitis1
3CompletedTreatmentGingivitis / Plaque, Dental1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Gel, dentifriceOral0.75 g/100g
Paste, dentifriceOral
Paste, dentifriceDental1000 mg/181g
Paste, dentifriceOral0.98 g/130g
Paste, dentifriceDental0.76 g/100g
PasteTopical0.22 g/100g
Paste, dentifriceOral1 mg/1g
PowderDental0.76 g/100g
Powder, dentifriceOral0.4332 g/57g
PasteDental0.76 g/1g
PowderDental0.1 g/100g
Paste, dentifriceOral0.016 g/160g
Tablet, chewableDental0.5 mg/1
PasteDental8.6 mg/1g
Paste, dentifriceDental1380 mg/200g
PasteDental1.10 mg/1g
Paste, dentifriceTopical
Paste, dentifriceOral0.1 g/100g
PasteOral
Paste, dentifriceDental
Paste, dentifriceDental0.0976 g/100g
Paste, dentifriceOral100 mg/100g
Paste, dentifriceDental0.15 g/100g
PasteOral0.76 mg/1g
PasteOral1.4 mg/1g
GelOral0.76 mg/1g
Gel, dentifriceDental.095 mg/1mg
PasteOral0.82 g/100g
PasteOral0.4 g/100g
Paste, dentifriceOral0.066 g/100g
Paste, dentifriceDental0.0076 g/1g
Paste, dentifriceOral0.13 g/100g
KitDental1.5 mg/1g
PasteDental11.4 mg/1g
Paste; paste, dentifriceDental
Paste, dentifriceDental1 mg/1g
Paste, dentifriceDental1.5 mg/1g
Paste, dentifriceDental1.1 mg/1g
Paste, dentifriceDental11.4 mg/1g
Gel, dentifriceDental1 mg/1g
Paste, dentifriceDental1.0 mg/1g
Paste, dentifriceDental60 mg/120g
SpongeOral0.05 g/100mL
PasteDental0.76 g/3g
Paste, dentifriceDental0.76 %
KitDental7.6 mg/1g
Paste, dentifriceDental0.76 mL/100mL
PasteDental0.208 g/160g
PasteDental0.156 g/120g
Paste, dentifriceDental172 mg/25g
Paste, dentifriceDental8 mg/1g
PasteDental1 mg/1g
Paste, dentifriceOral
Paste, dentifriceDental0.38 g/100g
Paste, dentifriceDental0.36 g/100g
PasteDental0.15 g/100g
Paste, dentifriceDental076 g/100g
Paste, dentifriceDental0.379 g/100g
Paste, dentifriceDental0.7581 g/100g
Paste, dentifriceDental0.758 g/100g
Paste, dentifriceDental0.5 g/100g
Paste, dentifriceDental1.2 g/200g
PasteOral0.912 g/120g
PasteDental1.4 g/200g
Paste, dentifriceOral0.91 g/120g
PasteTopical
Paste, dentifriceTopical0.76 g/100g
Paste, dentifriceTopical1.02 g/135g
Paste, dentifriceOral0.76 g/100g
PasteDental0.76 g/100g
Tablet, effervescentOral
PasteTopical0.75 g/1g
Paste, dentifriceOral0.88 g/100g
PasteOral0.88 g/100g
Paste, dentifriceDental0.8 g/100g
Paste, dentifriceDental0.85 mg/1g
PasteDental76 mg/1g
PasteDental0.35 g/100g
Paste, dentifriceDental0.84 g/100g
Paste, dentifriceOral.76 g/100g
Paste, dentifriceDental0.6 g/100g
PasteTopical0.76 g/100g
Gel, dentifriceDental0.14 g/100g
Paste, dentifriceDental7.6 mg/1g
PasteDental0.1 g/100g
GelOral0.76 g/100g
Gel, dentifriceDental0.76 g/100g
GelDental
PasteDental76 g/100g
Paste, dentifriceOral1.3 mg/1g
Gel, dentifriceOral1.3 mg/1g
Gel, dentifriceOral7.6 mg/1g
Paste, dentifriceDental.0076 g/1g
Gel, dentifriceOral0.88 g/100g
PasteDental0.88 g/100g
PasteDental
Paste, dentifriceBuccal
Paste, dentifriceDental2.43 mg/1g
Paste, dentifriceOral0.26 g/70g
Paste, dentifriceDental0.10 g/100g
KitDental
Gel, dentifriceDental8.4 mg/1g
Paste, dentifriceDental0.45 g/100g
PasteOral1 mg/1g
PasteOral7.6 mg/1g
PasteOral76 mg/1g
Paste, dentifriceDental0.83 g/100g
Paste, dentifriceDental0.4 g/100g
PasteOral
PasteDental8.4 mg/1g
PasteDental0.228 g/120g
GelDental0.4 g/30g
Paste, dentifriceDental0.15 g/150g
Paste, dentifriceDental1452 mg/220g
KitDental; Topical
Paste, dentifriceDental0.18 g/180g
PasteDental0.36 g/60g
GelDental0.36 g/60g
PasteDental1.4 mg/1g
PasteDental0.4 g/100g
PasteDental0.8 g/100g
PasteTopical0.74 g/100g
Paste, dentifriceDental
SuspensionDental
PasteDental
Paste, dentifriceDental1.3 mg/1mL
Paste, dentifriceOral0.83 g/100g
PasteDental1.5 mg/1g
Gel, dentifriceOral0.83 g/100g
Paste, dentifriceOral1.14 g/100g
PasteOral0.884 g/100g
PasteDental1.1 mg/1g
Paste, dentifriceTopical0.29 g/40g
Paste, dentifriceTopical0.31 g/90g
Paste, dentifriceOral0.31 g/90g
Gel, dentifriceDental0.88 g/100g
PasteDental7.6 mg/1g
Paste, dentifriceOral88.4 mg/1g
Paste, dentifriceOral1.5 mg/1g
Paste, dentifriceOral0.72 g/100g
Paste, dentifriceDental1.026 g/133g
Paste, dentifriceDental1.079 g/133g
Paste, dentifriceDental1460 mg/200g
Paste, dentifriceDental10.21 g/96.4g
Paste, dentifriceDental64 mg/8g
Paste, dentifriceDental0.1 g/100g
Paste, dentifriceDental; Oral1.4 mg/1g
LiquidDental0.4 g/100g
Gel, dentifriceOral0.758 g/100g
Paste, dentifriceDental1.4 mg/1g
CreamDental0.0014 g/1g
Paste, dentifriceDental0.833 mg/1g
KitOral0.13 g/100g
Paste, dentifriceOral0.74 g/100g
Paste, dentifriceDental1.125 g/150g
KitOral
KitDental; Oral
PasteDental1.15 mg/1g
CreamDental76 mg/181g
Paste, dentifriceDental0.0014 g/1g
Paste, dentifriceDental0.00243 g/1g
Paste, dentifriceDental11.5 mg/1g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.54ChemAxon
pKa (Strongest Acidic)0.1ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area63.19 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.35 m3·mol-1ChemAxon
Polarizability4.59 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on November 30, 2015 19:10 / Updated on April 16, 2021 12:23