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Displaying results 101 - 110 of 180585 in total
  1. Drug

    Clobazam

    go.drugbank.com/drugs/DB00349
    ApprovedIllicitInvestigational

    [A256963,A256868] This is likely because of clobazam's higher affinity to the α<sub>2</sub> subunit of the GABA<sub>A</sub> receptor, which mediates anxiolytic effects, than the α<sub>1</sub> subunit, … [A256868] Additionally, clobazam is believed to be a partial agonist to the GABA<sub>A</sub> receptor rather than non-selective full receptor agonists like 1,4-benzodiazepines, thus potentially explaining

    Categories: GABA-A Receptor Agonists, P-glycoprotein substratesSynonyms: 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione, 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
  2. Drug

    Dantrolene

    go.drugbank.com/drugs/DB01219
    ApprovedInvestigational

    Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin
  3. Drug

    ET140203

    go.drugbank.com/drugs/DB17196
    Investigational

    Synonyms: an autologous T-cell immunotherapy (ET140203), ET 1402L1-CART
  4. Drug

    Latanoprost

    go.drugbank.com/drugs/DB00654
    ApprovedInvestigational

    Another benefit latanoprost is that it can be administered once a day.[A184490] … Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998.

    Mixtures: Akistan Duo 50 Mikrogramm/ml + 5 mg/ml Augentropfen, Lösung, Xalacom 50 Mikrogramm/ml + 5 mg/ml AugentropfenCategories: Compounds used in a research, industrial, or household setting, Prostaglandins F, Synthetic
  5. Drug

    Delavirdine

    go.drugbank.com/drugs/DB00705
    ApprovedInvestigationalWithdrawn

    A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.

    Synonyms: (N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide), 2-(4-(5-methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamineCategories: Heterocyclic Compounds, 1-Ring, Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
  6. Drug

    Cannabidivarin

    go.drugbank.com/drugs/DB14050
    Investigational

    , which is a member of a large family of ion channels that are involved in the onset and progression of several types of epilepsy. … CBDV has also been shown to inhibit the activity of diacylglycerol (DAG) lipase-α, the primary enzyme responsible for the synthesis of the endocannabinoid, 2-arachidonoylglycerol (2-AG) [A33296, A33347

    Synonyms: 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-propylbenzene-1,3-diol, CBD-V
  7. Drug

    Leriglitazone

    go.drugbank.com/drugs/DB15021
    ApprovedInvestigational

    brain lesions and a Neurological Functional Score of 0 or 1. … [L147264][L147265] At the time of approval, no other medicines were authorized in the EU for gadolinium-negative cALD.[L147265]

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substratesSynonyms: 2,4-thiazolidinedione, 5-((4-(2-(5-(1-hydroxyethyl)-2-pyridinyl)ethoxy)phenyl)methyl)-, All-ambo-5-((4-(2-(5-(1-hydroxyethyl)pyridin-2-yl)ethoxy)phenyl)methyl)-1,3-thiazole-2,4(3H,5H)-dione
  8. Drug

    Thiopental

    go.drugbank.com/drugs/DB00599
    ApprovedInvestigationalVet approvedWithdrawn

    A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. … (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexSynonyms: 5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione, 2-Thio-5-ethyl-5-sec-pentylbarbituric acid
  9. Drug

    5'-deoxy-5'-piperidin-1-ylthymidine

    go.drugbank.com/drugs/DB08596
    Experimental

    Synonyms: 5'-deoxy-5'-piperidin-1-ylthymidine
  10. Drug

    beta-Sitosterol

    go.drugbank.com/drugs/DB14038
    Investigational

    Active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity.

    Synonyms: (3β)-Stigmast-5-en-3-ol, (24R)-ethylcholest-5-en-3β-olMixtures: BP Vit 3, Mi-Omega NF