Clobazam is a benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others..
- Mechanism
- Curator reviewed · 4 references
The exact mechanism of action for clobazam, a 1,5-benzodiazepine, is not fully understood but is thought to involve the potentiation of GABAergic neurotransmission resulting from binding at the benzodiazepine site of the GABAA receptor. Specifically, clobazam binds to the interface of the α2 and γ2-subunit of the GABAA receptor. It has a great affinity for the α2 subunit than the α1 subunit compared to other 1,4‐benzodiazepines. Binding of clobazam to the GABAA receptor causes chloride channels to open, resulting in an influx of chloride and thus hyperpolarization of neurons.
- Primary indication
- Clobazam is indicated for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older.Curator reviewed · 6 structured indications
- Formula / weight
- C16H13ClN2O2 · 300.74 g/mol (avg)
- First approval
- Canada, 2001 · United States, 2011
- Code names
- H-4723 · HR-376 · LM-2717
- Brand names
Resolves to
CXOXHMZGEKVPMT-UHFFFAOYSA-NSMILESCN1C2=C(C=C(Cl)C=C2)N(C2=CC=CC=C2)C(=O)CC1=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Clobazam, and which of those have an active Phase 3 trial?
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