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Zonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigationalZonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures. … [L42530,L42535] Zonisamide represents an alternative for patients that remain refractory to established antiepileptic drugs. In 1989, it was approved for commercial use in Japan.
Categories: Compounds used in a research, industrial, or household setting, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesProducts: ZONISAMID AL 25 MG HKP, ZONISAMID AL 50 MG HKPUridine triacetate
go.drugbank.com/drugs/DB09144ApprovedBy pre-administering with uridine (as the prodrug uridine triacetate), higher doses of 5-FU can be given allowing for improved efficacy and a reduction in toxic side effects [A18578]. … As a result of UMPS deficiency, patients experience a systemic deficiency of pyrimidine nucleotides, accounting for most symptoms of the disease.
Esmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnIt has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. … It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions.
Categories: Antihypertensive Agents Indicated for HypertensionProducts: Esmolol Hydrochloride in Water, Esmolol Hydrochloride In Sodium ChlorideAndexanet alfa
go.drugbank.com/drugs/DB14562ApprovedIt is marketed as Andexxa for intravenous injection or infusion and is indicated for the reversal of anticoagulation in combination with [rivaroxaban] and [apixaban] in cases of life-threatening or uncontrolled … Andexanet alfa retains the structural similarity to that of endogenous human factor Xa, but exists in its mature functional form without the need for activation via the intrinsic or extrinsic coagulation
Elbasvir
go.drugbank.com/drugs/DB11574ApprovedElbasvir is an inhibitor of NS5A, a protein essential for viral replication and virion assembly. … in the NS5A protein and previous treatment failure with [ribavirin], [peginterferon alfa-2a], [peginterferon alfa-2b], or other NS3/4A inhibitors like [boceprevir], [simeprevir], or [telaprevir].
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseMilrinone
go.drugbank.com/drugs/DB00235ApprovedInvestigational[A228333] As a PDE-III inhibitor, milrinone results in increased cAMP levels and improves cardiac function and peripheral vasodilation in acute decongested heart failure. … Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and
Mixtures: Milrinone Lactate in DextroseCategories: Compounds used in a research, industrial, or household settingMechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalThe FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL … A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas.
Categories: Compounds used in a research, industrial, or household settingSynonyms: 2,2'-dichloro-N-methyldiethylamine, N-methyl-bis(2-chloroethyl)amineFosinopril
go.drugbank.com/drugs/DB00492ApprovedInvestigationalwith diabetes mellitus and microalbuminuria or overt nephropathy. … Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals
Mixtures: FOSINOPRIL E IDROCLOROTIAZIDE AUROBINDO, FOSINOPRIL E IDROCLOROTIAZIDE AUROBINDOCategories: Agents Acting on the Renin-Angiotensin System, Antihypertensive Agents Indicated for HypertensionCeftolozane
go.drugbank.com/drugs/DB09050ApprovedInvestigational[L6685] It was approved by the FDA in 2014 for use in combination with [Tazobactam] for the treatment of serious infections, such as intra-abdominal infections and complicated urinary tract infections. … Ceftolozane is a semi-synthetic broad-spectrum fifth generation cephalosporin.
Mixtures: ZERBAXA POWDER FOR SOLUTION FOR INJECTION 1G/0.5G, Zerbaxa 1.5g powder for solution for injectionSynonyms: -Amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl)-7-([(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-eneTaurocholic acid
go.drugbank.com/drugs/DB04348ApprovedIt acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.
Mixtures: Lax-BO Tab, Pro Gest TabCategories: Compounds used in a research, industrial, or household setting