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Sotorasib
go.drugbank.com/drugs/DB15569ApprovedInvestigationalSotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen. … [A187550] Mutant KRAS discovered in 1982 but was not considered a druggable target until the mid-2010s.[A235168] It is the first experimental KRAS inhibitor.
Categories: Antineoplastic and Immunomodulating AgentsProducts: LUMAKRAS FILM-COATED TABLET 120MGCod liver oil
go.drugbank.com/drugs/DB11321ApprovedNutraceuticalVet approvedIt is used as an adjunct treatment and preventative therapy of rickets, osteomalacia and osteoporosis while meeting the consumption criteria. … Cod liver oil is extracted from the liver of cod fish and mainly consists of omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
Mixtures: CURACID Dermal for cuts and burnsCategories: Diet, Food, and NutritionUrsodeoxycholic acid
go.drugbank.com/drugs/DB01586ApprovedInvestigational[A256272] UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary biliary cirrhosis in 1996. … [A256267,A256463] UDCA was first characterized in the bile of the Chinese black bear and is formed by 7b-epimerization of [chenodeoxycholic acid], which is a primary bile acid.
Categories: Bile Acids and Salts, Bile and Liver TherapyProducts: URSOFALK 250MG, URSO 1A PHARMA 250MGOcrelizumab
go.drugbank.com/drugs/DB11988ApprovedInvestigationalIt was later approved by Health Canada in August 2017, making the drug the first available treatment for PPMS in both the US and Canada. … [L1199] In phase 3 clinical trials of patients with PPMS, treatment with ocrelizumab led to lower clinical and MRI progression rates compared to placebo.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: OCREVUS 300mg/10mL Concentrate for Solution for Infusion, OCREVUS® CONCENTRADO PARA SOLUCION PARA INFUSION 300MG/10MLAmaranthus retroflexus pollen
go.drugbank.com/drugs/DB10381ApprovedAmaranthus retroflexus pollen is the pollen of the Amaranthus retroflexus plant. Amaranthus retroflexus pollen is mainly used in allergenic testing.
Categories: Non-Standardized Pollen Allergenic ExtractProducts: Pollens - Weeds and Garden Plants, Pigweed, Rough Redroot Amaranthus retroflexusSarilumab
go.drugbank.com/drugs/DB11767ApprovedInvestigational[A27262] Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approved in May 2017 and followed by EU approval in June 2017 for the treatment of moderate to severe rheumatoid … [A27265] RA is a chronic inflammatory disease characterized by polyarthritis, and its treatment has been challenged by the different responses in every patient.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: KEVZARA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 150MG, KEVZARA Solution for Injection in Pre-filled Pen 150mgGolimumab
go.drugbank.com/drugs/DB06674ApprovedInvestigationalThus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with moderate to severe active rheumatoid arthritis (RA), (ii) alone or as an adjunct to methotrexate … Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: SIMPONI SOLUTION FOR INJECTION IN PRE-FILLED PEN 45MG/0.45ML, SIMPONI 100MG FERErgotamine
go.drugbank.com/drugs/DB00696ApprovedIt is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Mixtures: Ergotamine Tartrate and Caffeine, Ergotamine Tartrate and CaffeineCategories: Ergot Alkaloids and Derivatives, Analgesics, Non-NarcoticAsciminib
go.drugbank.com/drugs/DB12597ApprovedInvestigational[A241065] Asciminib is unique in that it acts as an allosteric inhibitor, binding at the myristoyl pocket of the BCR-ABL1 protein and locking it into an inactive conformation. … Existing inhibitors of ABL compete at the ATP binding sites of these proteins and can be classified into those that target the active conformation of the kinase domain ([dasatinib], [bosutinib]) and those
Categories: Antineoplastic and Immunomodulating AgentsProducts: Scemblix 20mg film-coated tablet, Scemblix 40mg film-coated tabletAzacitidine
go.drugbank.com/drugs/DB00928ApprovedInvestigationalAs an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and inhibiting protein and DNA synthesis. … [A1407] Due to its anti-neoplastic activity and its ability to inhibit methylation in replicating DNA, azacytidine has been used mainly used in the treatment of myelodysplastic syndromes (MDS) and acute
Categories: Antineoplastic and Immunomodulating Agents, Nucleic Acids, Nucleotides, and NucleosidesProducts: Vidaza powder for suspension for injection 100mg/vial, AZADINE POWDER FOR SUSPENSION FOR INJECTION 100MG/VIAL