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Quizartinib
go.drugbank.com/drugs/DB12874ApprovedInvestigationalcytarabine consolidation, followed by a maintenance monotherapy resulted in a 22% reduction in the risk of death. … Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug developed specifically targeting FLT3, as other agents with FLT3 inhibition activities were investigated
Synonyms: N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)ureaCategories: P-glycoprotein inhibitors, P-glycoprotein substratesAC-003
go.drugbank.com/drugs/DB22691InvestigationalAC-003 is a selective, oral small-molecule inhibitor of receptor-interacting protein kinase 1 (RIPK1). … [L53458,L53463] By inhibiting RIPK1 kinase activity, AC-003 thereby inhibits RIPK1-mediated cell death and inflammation.
Synonyms: Tetrahydro-2H-pyran-4-yl 7-(2-(cyclopropanecarboxamido)- imidazo[1,2-a]pyridin-6-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-1-carboxylate, Tetrahydro-2H-pyran-4-yl 7-(2-(cyclopropanecarboxamido)-imidazo[1,2-a]pyridin-6-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-1-carboxylateSalts: Tetrahydro-2H-pyran-4-yl 7-(2-(cyclopropanecarboxamido)-imidazo[1,2-a]pyridin-6-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-1-carboxylate hydrochloride2-Amino-4-(4-Amino-Cyclohexa-2,5-Dienyl)-Butyric Acid
go.drugbank.com/drugs/DB02725ExperimentalSynonyms: 2-Amino-4-(4-Amino-Cyclohexa-2,5-Dienyl)-Butyric Acid(2R,3R)-2,3-Dihydroxy-4-oxo-4-(propylamino)butanoic acid
go.drugbank.com/drugs/DB03390ExperimentalSynonyms: N-Propyl-L-tartramate, (2R,3R)-2,3-Dihydroxy-4-oxo-4-(propylamino)butanoic acid(2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
go.drugbank.com/drugs/DB07736ExperimentalSynonyms: (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide(2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
go.drugbank.com/drugs/DB07737ExperimentalSynonyms: (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamideDaplusiran
go.drugbank.com/drugs/DB19331InvestigationalDaplusiran is under investigation in clinical trial NCT06537414 (A Study of Sequential Therapy With Daplusiran/tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis … B (CHB)).
Synonyms: RNA, (AM-SP-(2'-DEOXY-2'-FLUORO)G-SP-AM-SP-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)U-GM-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY, -2'-FLUORO)G-UM-(2'-DEOXY-2'-FLUORO)C-CM-AM-SP-CM),Obecabtagene autoleucel
go.drugbank.com/drugs/DB17362ApprovedInvestigationalObecabtagene autoleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with a fast off-rate binding profile for CD19. … [A265040,A265045] It works by targeting B-cell-specific CD19 surface markers present on malignant B cells.
Categories: Genetically-modified Autologous T Cells, CD19-Directed Genetically Modified Autologous T-cell ImmunotherapiesSynonyms: A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O, AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) OBTAINED BY APHERESIS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODINGalpha-Ketoisocaproic acid
go.drugbank.com/drugs/DB03229ExperimentalSynonyms: 4-Methyl-2-oxopentanoate, 2-oxo-4-methylpentanoic acidSalts: Calcium 4-methyl-2-oxovalerateDiethylamino hydroxybenzoyl hexyl benzoate
go.drugbank.com/drugs/DB11269ApprovedDiethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. … It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability [A33171].
Synonyms: Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoateInternational brands: Uvinul A Plus