This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Quizartinib
- DrugBank Accession Number
- DB12874
- Background
Quizartinib is under investigation in Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies. It is a potent inhibitor of FLT3.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Quizartinib (DB12874)
- Weight
- Average: 560.67
Monoisotopic: 560.220574708 - Chemical Formula
- C29H32N6O4S
- Synonyms
- N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea
- Quizartinib
- Quizartinibum
- External IDs
- AC 010220
- AC 220
- AC-010220
- AC-220
- AC010220
- AC220
Pharmacology
- Indication
Not Available
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
In preclinical studies, Quizartinib demonstrated dose-dependent activity and favorable drug-like profiles in bioavailability, pharmacokinetics, cytochrome P450 (CYP) liability, and absorption, distribution, metabolism, excretion (ADME).
- Mechanism of action
Quizartinib potently inhibits FLT3, a kinase that is mutated in approximately one-third of acute myeloid leukemia cases, and patients with FLT3 mutations are less responsive to traditional therapies.
Target Actions Organism UReceptor-type tyrosine-protein kinase FLT3 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareArticaine The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Articaine. Benzocaine The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Benzocaine. Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Benzyl alcohol. Bupivacaine The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Bupivacaine. Butacaine The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Butacaine. Butamben The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Butamben. Capsaicin The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Capsaicin. Chloroprocaine The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Chloroprocaine. Cinchocaine The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Cinchocaine. Cocaine The risk or severity of methemoglobinemia can be increased when Quizartinib is combined with Cocaine. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Quizartinib dihydrochloride WK7Q6ZIZ10 1132827-21-4 DHYPGRVMIOATAE-UHFFFAOYSA-N
Categories
- ATC Codes
- L01EX11 — Quizartinib
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Azoles
- Sub Class
- Imidazoles
- Direct Parent
- Phenylimidazoles
- Alternative Parents
- N-phenylureas / Benzothiazoles / Alkyl aryl ethers / N-substituted imidazoles / Morpholines / Imidolactams / Thiazoles / Heteroaromatic compounds / Isoxazoles / Ureas show 8 more
- Substituents
- 1,3-benzothiazole / 4-phenylimidazole / 5-phenylimidazole / Alkyl aryl ether / Amine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Carbonic acid derivative / Carbonyl group show 22 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7LA4O6Q0D3
- CAS number
- 950769-58-1
- InChI Key
- CVWXJKQAOSCOAB-UHFFFAOYSA-N
- InChI
- InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
- IUPAC Name
- 3-(5-tert-butyl-1,2-oxazol-3-yl)-1-(4-{10-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0²,⁶]dodeca-1(8),3,5,9,11-pentaen-4-yl}phenyl)urea
- SMILES
- CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C=C2)C2=CN3C(SC4=C3C=CC(OCCN3CCOCC3)=C4)=N2)=NO1
References
- General References
- Not Available
- External Links
- KEGG Drug
- D09955
- PubChem Compound
- 24889392
- PubChem Substance
- 347829030
- ChemSpider
- 24640357
- BindingDB
- 50300690
- ChEBI
- 90217
- ChEMBL
- CHEMBL576982
- ZINC
- ZINC000043204002
- PDBe Ligand
- P30
- Wikipedia
- Quizartinib
- PDB Entries
- 4rt7 / 4xuf
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Active Not Recruiting Treatment Acute Myeloid Leukemia / Leukemias 1 3 Completed Treatment Acute Myeloid Leukemia 1 3 Withdrawn Treatment Acute Myeloid Leukemia 1 2 Active Not Recruiting Treatment Acute Myeloid Leukemia 1 2 Completed Treatment Acute Myeloid Leukemia 3 2 Terminated Treatment Acute Myeloid Leukemia 1 2 Unknown Status Treatment Acute Myeloid Leukemia / FLT3-ITD Mutation 1 2, 3 Unknown Status Treatment Acute Myeloid Leukemia / Myelodysplastic Syndromes (MDS) 1 1 Completed Treatment Acute Myeloid Leukemia 4 1 Completed Treatment Acute Myeloid Leukemia / Leukemias / Myelodysplastic Syndromes (MDS) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0509 mg/mL ALOGPS logP 5.13 ALOGPS logP 5.16 Chemaxon logS -4 ALOGPS pKa (Strongest Acidic) 10.43 Chemaxon pKa (Strongest Basic) 6.62 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 106.16 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 168.24 m3·mol-1 Chemaxon Polarizability 61.51 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Vascular endothelial growth factor-activated receptor activity
- Specific Function
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells...
- Gene Name
- FLT3
- Uniprot ID
- P36888
- Uniprot Name
- Receptor-type tyrosine-protein kinase FLT3
- Molecular Weight
- 112902.51 Da
Drug created at October 21, 2016 00:57 / Updated at February 21, 2021 18:54