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Familial periodic paralysis
go.drugbank.com/conditions/DBCOND0008063Drugs: AcetazolamideSynonyms: Periodic paralysis ISipuleucel-T
go.drugbank.com/drugs/DB06688ApprovedInvestigationalThe treatment initially cost $93,000 at the time of FDA approval, but rose to over $100,000 in 2014. … Sipuleucel-T is marketed under the brand name Provenge by Dendreon Corporation. Sipuleucel-T was approved by the U.S.
Synonyms: Sipuleucel-TCategories: sipuleucel-T, Intercellular Adhesion Molecule-1Tralokinumab
go.drugbank.com/drugs/DB12169ApprovedInvestigationalIt neutralizes IL-13 activity by inhibiting its ability to bind with receptors, thus helping to alleviate AD symptoms. … US in December 2021.
Calcium carbimide
go.drugbank.com/drugs/DB09116ApprovedWithdrawnIts effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic product acetaldehyde. … Calcium carbimide was conceived as an alternative for the treatment of alcoholism with a reduced side effect profile either when it is consumed accompanied by alcohol or without it.
Categories: Drugs Used in Addictive Disorders, Drugs Used in Alcohol DependenceSynonyms: Cyanamide, calcium salt (1:1), methanediimine, calcium salt (1:1)Carbon monoxide
go.drugbank.com/drugs/DB11588ApprovedInvestigationalCarbon monoxide (CO) is a colorless, odorless, and tasteless gas that has a slightly lower density than air. … The DLCO measures the ability of the lungs to transfer gas from inhaled air to the red blood cells in pulmonary capillaries. The DLCO test is both convenient and simple for the patient to undergo.
Synonyms: carbon(II) oxide, COMixtures: Lung Diffusion Test Mix No Ne Co, Co-NE-O2-N2 MixtureDomperidone
go.drugbank.com/drugs/DB01184ApprovedInvestigationalVet approvedA specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one, 5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinoneFlupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawnIt is approved for use in Canada and other countries around the world, but not in the US. … Flupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is produced by esterification of cis(Z)‐flupentixol with decanoic acid.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein inhibitorsProducts: Fluanxol Depot 2% -liq Im 20mg/ml, FLUANXOL DEPOT 20MG/ML IM ENJ. SOLUSYON, 1 ADETHydroxyprogesterone caproate
go.drugbank.com/drugs/DB06789ApprovedIn April 2023, the FDA withdrew its approval of Makena and its generics given an unfavorable risk-to-benefit assessment.[L46113] … Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S.
Mixtures: GRAVIDINONA 2 MLCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 InducersInclisiran
go.drugbank.com/drugs/DB14901ApprovedInvestigationalBy binding to PCSK9 messenger RNA, inclisiran prevents protein translation of PCSK9, leading to decreased concentrations of PCSK9 and plasma concentrations of LDL cholesterol. … [L28178] Inclisiran was later approved by the FDA on December 22, 2021, for the treatment of heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease in adults
Categories: Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia, Compounds used in a research, industrial, or household settingProducts: LEQVIO SOLUTION FOR INJECTION IN PREFILLED SYRINGE 284 MG/1.5 ML, Sybrava 284mg/1.5ml Solution for Injection in Pre-filled SyringeCarglumic acid
go.drugbank.com/drugs/DB06775ApprovedInvestigationalCarglumic acid was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010. … This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death.
Synonyms: N-Carbamyl-L-glutamate, L-N-Carbamoylglutamic acidCategories: Carbamoyl Phosphate Synthetase 1 Activator, Carbamoyl Phosphate Synthetase 1 Activators