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Reslizumab
go.drugbank.com/drugs/DB06602ApprovedInvestigationalReslizumab is a humanized interleukin-5 (IL-5) antagonist monoclonal antibody (IgG4 kappa) that is produced by recombinant DNA technology in murine myeloma non-secreting 0 (NS0) cells. IL-5 is a pro-inflammatory cytokine that is responsi...
Edaravone
go.drugbank.com/drugs/DB12243ApprovedInvestigationalEdaravone is a free radical scavenger and neuroprotective agent with antioxidant properties. It has three tautomers. Edaravone works to scavenge reactive oxygen species, which have been implicated in neurological disorders, such as amyot...
Licorice
go.drugbank.com/drugs/DB10675ApprovedLicorice allergenic extract is used in allergenic testing.
Mixtures: NELLCO SPECIAL OBH PEOxycodegol
go.drugbank.com/drugs/DB14146InvestigationalLoxicodegol was developed by Nektar Therapeutics as an opioid analgesic with low abuse potential for the treatment of chronic pain . The lack of abuse potential is believed to be due to the drug's slow rate of entry into brain, a unique ...
Bezisterim
go.drugbank.com/drugs/DB05212InvestigationalCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesClopamide
go.drugbank.com/drugs/DB13792InvestigationalLike thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure.
Potassium alum
go.drugbank.com/drugs/DB09087ApprovedWithdrawnPotassium alum is considered by the FDA as a generally recognized as safe (GRAS) substance. It is an inorganic salt, also called potassium aluminum sulfate with a formula of AlK(SO4)2 that is predominantly produced in the dodecahydrate f...
Mixtures: Gingicord W Epineph and Alum Size No 1, Gingicord W Epineph and Alum Size No 3Troglitazone
go.drugbank.com/drugs/DB00197ApprovedWithdrawnTroglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesZonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigationalZonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium c...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesRepaglinide
go.drugbank.com/drugs/DB00912ApprovedInvestigationalRepaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the p...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates