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Halofantrine
go.drugbank.com/drugs/DB01218ApprovedWithdrawnHalofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. … Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.
Categories: Antiparasitic Products, Insecticides and RepellentsProducts: Halfan - Tab 250mgUrsodeoxycholic acid
go.drugbank.com/drugs/DB01586ApprovedInvestigational[A256272] UDCA works by replacing the hydrophobic or more toxic bile acids from the bile acid pool.[A256272] … [A256272] UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary biliary cirrhosis in 1996.
Categories: Bile Acids and Salts, Bile and Liver TherapyProducts: URSOFALK 250MG, URSO 1A PHARMA 250MGMefloquine
go.drugbank.com/drugs/DB00358Approved[L30618] Despite this, malaria remains a significant cause of morbidity and mortality; 90% of deaths from malaria occur in Africa. … It was approved by the FDA in 1989, and was first marketed by Hoffman Laroche.
Categories: artesunate and mefloquine, Antiparasitic Products, Insecticides and RepellentsProducts: Lariam Tab 250mgSotorasib
go.drugbank.com/drugs/DB15569ApprovedInvestigational[L34288] This mutation makes up >50% of all KRAS mutations.[A187550] Mutant KRAS discovered in 1982 but was not considered a druggable target until the mid-2010s. … Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.
Categories: Antineoplastic and Immunomodulating AgentsProducts: LUMAKRAS FILM-COATED TABLET 120MGBupivacaine
go.drugbank.com/drugs/DB00297ApprovedInvestigationalBupivacaine is a widely used local anesthetic agent.
Mixtures: ReadySharp-K, Bupivacaine Hci and EpinephrineCategories: bupivacaine and meloxicamAvanafil
go.drugbank.com/drugs/DB06237ApprovedIn comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively
Categories: Genito Urinary System and Sex HormonesProducts: SPEDRA TABLET 100MG, Spedra 100mg TabletsBimatoprost
go.drugbank.com/drugs/DB00905ApprovedInvestigationalBimatoprost, marketed by Allergan, is administered in both the ophthalmic solution and implant form. … [L6910] It was initially approved by the FDA in 2001 for ocular hypertension and later approved for hypothrichosis in 2008, as eyelash growth became a desirable adverse effect for patients using this drug
Mixtures: GANFORT® UD SOLUCION OFTALMICA, GANFORT 0.3MG/ML+5MG/MLCategories: Antiglaucoma Preparations and MioticsAzacitidine
go.drugbank.com/drugs/DB00928ApprovedInvestigationalIt differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. … As an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and inhibiting protein and DNA synthesis.
Categories: Antineoplastic and Immunomodulating Agents, Nucleic Acids, Nucleotides, and NucleosidesProducts: Vidaza powder for suspension for injection 100mg/vial, AZADINE POWDER FOR SUSPENSION FOR INJECTION 100MG/VIALRavulizumab
go.drugbank.com/drugs/DB11580ApprovedInvestigational[L39690] Ravulizumab was engineered from [eculizumab], another complement inhibitor, to increase the duration of action and reduce the frequency of drug administration. … [A244465] Ravulizumab was first approved by the FDA on December 21, 2018, for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome in children and adults.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: ULTOMIRIS ® RAVULIZUMAB 100MG/ML., Ultomiris 100mg/mL Concentrate For Solution For InfusionOctreotide
go.drugbank.com/drugs/DB00104ApprovedInvestigational[L14501] In most cases, it results from an anterior pituitary growth hormone-releasing tumor. … [L14513] Additionally, it is used for the treatment of acromegaly and symptoms arising from various tumors, including carcinoid tumors and vasoactive intestinal tumors (VIPomas).
Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsProducts: SANDOSTATIN LAR 20MG, SANDOSTATIN LAR 10MG