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Glecaprevir
go.drugbank.com/drugs/DB13879ApprovedInvestigationalAs of June 2025, the FDA approved an expanded indication for Mavyret, making it the first and only direct-acting antiviral therapy approved for the treatment of both acute and chronic HCV in patients aged … Mavyret is also indicated for HCV genotype 1-infected patients who have been previously treated with regimens either containing an NS5A inhibitor or an NS3/4A protease inhibitor, but not both [L940].
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseSelegiline
go.drugbank.com/drugs/DB01037ApprovedInvestigationalVet approvedIt may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability.
Categories: Antidepressive Agents Indicated for Depression, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesPretomanid
go.drugbank.com/drugs/DB05154ApprovedInvestigational[L8048,L8066] Unlike other therapeutic regimens for the treatment of resistant TB, which may take 18 months or longer and may not be effective, the pretomanid-containing regimen allows for a more efficacious … Research in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy regimens.
Categories: Antiinfectives for Systemic Use, Drugs for Treatment of TuberculosisGlimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigationalThe main effect of SUs is thought to be effective when residual pancreatic β-cells are present,[A177715] as they work by stimulating the release of insulin from the pancreatic beta cells and they are also … Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes to lower blood glucose levels.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesDexbrompheniramine
go.drugbank.com/drugs/DB00405ApprovedDexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria.
Mixtures: M-end Max D, Alahist PECategories: Antihistamines for Systemic UseUnoprostone
go.drugbank.com/drugs/DB06826ApprovedWithdrawnThe main indication of Unoprostane is treatment of glucoma.
Leptin Receptor Deficiency Obesity
go.drugbank.com/conditions/DBCOND0081474Drugs: SetmelanotideSynonyms: Leptin Receptor Deficiency Obesityalpha-Tocopherol succinate
go.drugbank.com/drugs/DB14001ApprovedNutraceuticalVet approvedAlpha-tocopherol succinate is subsequently most commonly indicated for dietary supplementation in individuals who may demonstrate a genuine deficiency in vitamin E. … This biologic action of vitamin E consequently continues to generate ongoing interest and study in whether or not its antioxidant abilities may be used to help assist in preventing or treating a number
Mixtures: For Men, Formula Ma-vitamin E & Zinc TabRelmacabtagene autoleucel
go.drugbank.com/drugs/DB18979InvestigationalSynonyms: AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) TRANSDUCED WITH A NONREPLICATIVE SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR ENCODING A CHIMERIC ANTIGEN RECEPTORFlupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawnIt is used for the management of chronic schizophrenia in patients whose main manifestations do not include excitement, agitation or hyperactivity. … [L31808] It has been marketed to manage symptoms of depression in patients who may or may not exhibit signs of anxiety.
Categories: P-glycoprotein inhibitors, Adrenergic alpha-1 Receptor Antagonists