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Lofexidine
go.drugbank.com/drugs/DB04948ApprovedInvestigationalLofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. … [A33084] It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hypertension than clonidine.
Categories: Drugs Used in Opioid Dependence, Drugs Used in Addictive DisordersZiconotide
go.drugbank.com/drugs/DB06283ApprovedInvestigational[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be … [A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.
Categories: Compounds used in a research, industrial, or household settingAcetylcarnitine
go.drugbank.com/drugs/DB08842ApprovedInvestigationalAcetylcarnitine can be synthesized, but it is also naturally found in adequate amounts in healthy humans. … Acetylcarnitine is an investigational drug in the United states, Italy, United Kingdom, China, Israel, and Norway, and it is approved in Italy, Portugal, Argentina, Chile, Philippines, Australia, and India
Synonyms: acetyl-L-carnitine, O-acetyl-L-carnitineInternational brands: Memorx IQ PlusFlortaucipir F-18
go.drugbank.com/drugs/DB14914ApprovedInvestigational[A203933] It is used as a marker in positron emission tomography (PET) imaging of patients suspected of having Alzheimer's disease. … It was approved by the FDA on May 28, 2020, for sale by Avid Radiopharmaceuticals under the name TAUVID™ and is the first FDA-approved molecule for imaging aggregated tau protein in the brain.[L14114]
Categories: Compounds used in a research, industrial, or household settingLithium cation
go.drugbank.com/drugs/DB01356ApprovedInvestigationalWithdrawnThe active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several … It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches.
Synonyms: LI, Li(+)Deferiprone
go.drugbank.com/drugs/DB08826ApprovedInvestigationalDeferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. … Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired.
Categories: Compounds used in a research, industrial, or household settingProducts: FERRIPROX 100 MG/ML SURUP, 500 ML, GPO-L-One Tablet 500mgBexagliflozin
go.drugbank.com/drugs/DB12236ApprovedInvestigationalIts use is not recommended in patients with type 1 diabetes since it may increase their risk of diabetic ketoacidosis.[L44758] … [A256413] SGLT2 is responsible for 60% to 90% of renal glucose re-uptake, and unlike other isoforms such as SGLT1, SGLT2 is mainly expressed in the kidney.
Categories: Drugs Used in DiabetesGlimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigationalIt is commonly marketed under the brand name Amaryl as oral tablets and is typically administered once daily. … It is sometimes classified as a third-generation SU because it has larger substitutions than other second-generation SUs.
Categories: Drugs Used in DiabetesProducts: GLIMEPIRID AL 1MG, GLIMEPIRID AL 2MGGadoxetic acid
go.drugbank.com/drugs/DB08884ApprovedInvestigationalGadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. … Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug.
Categories: Compounds used in a research, industrial, or household settingProducts: Primovist 0.25 mmol/ml Solution for injection, PRIMOVIST 0.25 MMOL/ML, SOLUTION FOR INJECTIONTorasemide
go.drugbank.com/drugs/DB00214ApprovedInvestigationalTorasemide is a high-ceiling loop diuretic.[A174463] Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. … [A319] Torasemide was first approved for clinical use by the FDA in 1993.[L5257]
Products: TORASEMID AL 5MG TABL, TORASEMID AL 10MG TABL