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Displaying results 1181 - 1190 of 7604 in total
  1. Drug

    Ritlecitinib

    go.drugbank.com/drugs/DB14924
    ApprovedInvestigational

    In June 2023, it was approved by the FDA for the treatment of severe alopecia areata in adults and adolescents 12 years and older.[L47092,L47127] It was further approved by the EMA in September 2023.

  2. Target

    Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

    go.drugbank.com/bio_entities/BE0000571
    TargetEnzymeHumans

    Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex (PubMed:17474719, PubMed:19081061). The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby li...

    Polypeptides: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
  3. Drug

    Levallorphan

    go.drugbank.com/drugs/DB00504
    Approved

    It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants

    Categories: Heterocyclic Compounds with 4 or More Rings
  4. Drug

    Baloxavir marboxil

    go.drugbank.com/drugs/DB13997
    ApprovedInvestigational

    [A251760] Baloxavir marboxil was first globally approved in Japan in February 2018,[A39895] followed by the US approval in October, 2018.

    Categories: Antivirals for Systemic Use, Antiinfectives for Systemic Use
  5. Drug

    Lithium cation

    go.drugbank.com/drugs/DB01356
    ApprovedInvestigationalWithdrawn

    It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. … The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several

  6. Drug

    Clonazepam

    go.drugbank.com/drugs/DB01068
    ApprovedIllicitInvestigational

    [FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history … [FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.

  7. Drug

    Retapamulin

    go.drugbank.com/drugs/DB01256
    Approved

    Retapamulin, marketed by GlaxoSmithKline as the ointment Altabax, is an antibiotic for skin infections like impetigo. It was approved by the FDA in April 2007.

    Categories: Antibiotics for Topical Use
  8. Drug

    Elbasvir

    go.drugbank.com/drugs/DB11574
    Approved

    for genotype 1 and 97% and 100% for genotype 4 after 12 weeks of treatment. … of SARS-CoV-2, the human coronavirus responsible for the COVID-19 pandemic.

    Categories: Antivirals for Systemic Use, Antiinfectives for Systemic Use
  9. Drug

    Tick-borne encephalitis vaccine (whole virus, inactivated)

    go.drugbank.com/drugs/DB16611
    ApprovedInvestigational

    [A237520] Due to a paucity of effective safe and effective acute therapeutic agents, vaccination remains the most important defence against TBE in endemic areas. … [A237505, A237520] While some patients recover fully following neurological TBE, neurological sequelae can last for years and rare chronic forms of the disease have also been noted.

  10. Drug

    Vaborbactam

    go.drugbank.com/drugs/DB12107
    ApprovedInvestigational

    Vabomere consists of vaborbactam and [Meropenem] for intravenous administration. … In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the FDA for the treatment of adult patients with complicated urinary tract infections (cUTI).

    Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use