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Zolpidem
go.drugbank.com/drugs/DB00425ApprovedInvestigationalZolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. … Research also shows that zolpidem is rapid and effective in restoring brain function for patients in a vegetative state following brain injury.
Mixtures: Sentrazolpidem PM-5Categories: GABA-A Receptor Agonists, gamma-Aminobutyric Acid A Receptor Positive ModulatorSulfanilamide
go.drugbank.com/drugs/DB00259ApprovedWithdrawnSulfanilamide is a molecule containing the sulfonamide functional group attached to an aniline.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsSynonyms: p-aminobenzenesulfamide, p-aminobenzenesulfonamideFentanyl
go.drugbank.com/drugs/DB00813ApprovedIllicitInvestigationalVet approvedFentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. … Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: FENTANYL-PF 100 MCG/2 ML I.V./I.M. ENJEKSİYONLUK ÇÖZELTİ, 10 ADET, FENTANYL-PF 500 MCG/10 ML I.V./I.M. ENJEKSİYONLUK ÇÖZELTİ, 1 ADETAlendronic acid
go.drugbank.com/drugs/DB00630ApprovedInvestigationalAlendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111].
Mixtures: OSSOFORTIN A 70 MG+1200 MG/800 IU TEDAVİ PAKETİ, 4+24 ADETProducts: Ag-alendronate, Ava-alendronateTheophylline
go.drugbank.com/drugs/DB00277ApprovedInvestigationalMechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. … A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities.
Mixtures: TUSBRON-A JARABE, TEOSEL 200 MG IV İNFÜZYONLUK ÇÖZELTİ (100 ML SETLI)Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexTioconazole
go.drugbank.com/drugs/DB01007ApprovedTioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. … In addition to being an antifungal, tioconazole also has antibacterial effects on certain Gram-positive cocci bacteria.[L50166]
Mixtures: Gynecure Tandempk.vag Ov.300mg/vulv.crm1%w/w, Gynecure Tandempk.vag Ov.300mg/vulv.crm1%w/wCategories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP2C19 InhibitorsZolmitriptan
go.drugbank.com/drugs/DB00315ApprovedInvestigationalZolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)<sub>1B/1D/(1F)</sub> receptor agonists used to treat acute migraine. … [A193791] Triptans can be administered alone or in combination with an NSAID like [naproxen], and represent the current "gold standard" for acute migraine treatment.
Categories: Monoamine Oxidase A Substrates, Cytochrome P-450 SubstratesProducts: Ag-zolmitriptan ODT, ZOLMITRIPTAN AL 5MGMirtazapine
go.drugbank.com/drugs/DB00370ApprovedInvestigational[T595, L6157] The effects of this drug may be observed as early as 1 week after beginning therapy. … Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSynonyms: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepineClotrimazole
go.drugbank.com/drugs/DB00257ApprovedInvestigationalVet approvedAs well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. … well as athlete's foot [A174097].
Mixtures: SAEROGENTA-A CREAMCategories: P-glycoprotein inducers, P-glycoprotein inhibitorsParoxetine
go.drugbank.com/drugs/DB00715ApprovedInvestigationalParoxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. … Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: (−)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine