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Tizanidine
go.drugbank.com/drugs/DB00697ApprovedInvestigationalInitially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons … Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury [T574].
Synonyms: 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazoleInternational brands: Sirdalud MRMiltefosine
go.drugbank.com/drugs/DB09031ApprovedInvestigationalMiltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent. … It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease.
Categories: P-glycoprotein substratesSynonyms: hexadecyl 2-(trimethylazaniumyl)ethyl phosphateDonepezil
go.drugbank.com/drugs/DB00843ApprovedInvestigationalIn 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. … [L7916,L7937] A donepezil transdermal delivery system, Adlarity, was approved by the FDA in March 2022 for the treatment of Alzheimer's dementia.
Mixtures: EBICOMB 5 MG/20 MG EFERVESAN TABLET, 100 ADET, EBICOMB 10 MG/20 MG EFERVESAN TABLET, 100 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNitrazepam
go.drugbank.com/drugs/DB01595ApprovedA benzodiazepine derivative used as an anticonvulsant and hypnotic.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 InhibitorsSynonyms: 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one, 2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-oneAminolevulinic acid
go.drugbank.com/drugs/DB00855ApprovedInvestigationalA compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]
Synonyms: 5-ALA, δ-ALAProducts: Alacare 8 mg wirkstoffhaltiges Pflaster, GLIOLAN, POWDER FOR ORAL SOLUTION, 30 MG/MLDolichovespula arenaria venom protein
go.drugbank.com/drugs/DB10957ApprovedDolichovespula arenaria venom protein is an extract of Dolichovespula arenaria venom. Dolichovespula arenaria venom protein is used in allergenic testing.
Mixtures: Mixed Vespid Venom Protein Multidose 13.0 Ml (3900 Mcg), Hymenoptera Venom Product-mixed Vespid Venom Protein (1650 Mcg)Products: Hymenoptera Venom Products-yellow Hornet Venom Protein (550 Mcg), Venomil Inj 10mcg/ml Yellow HornetUrea C-13
go.drugbank.com/drugs/DB09510ApprovedInvestigationalTo detect H. pylori, urea labeled with 13C is swallowed by the patient. … H pylori is a common stomach bacteria that has been linked to a variety of upper gastrointestinal disorders such as gastritis, gastric and peptic ulcers, stomach cancer, and gastric mucosa-associated lymphoid-tissue
Synonyms: Urea 13 C, Urea C 13Products: Diabact UBT 50 mg Tabletten, TAU-KIT® 100 MGRizatriptan
go.drugbank.com/drugs/DB00953ApprovedInvestigationalRizatriptan is a second-generation triptan [A258918] and a selective 5-HT<sub>1B and 5-HT1D</sub> receptor agonist.
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSynonyms: N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine, N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamineClofazimine
go.drugbank.com/drugs/DB00845ApprovedInvestigationalWithdrawnClofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. … It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin and bodily fluids.
Categories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 CYP3A InhibitorsProducts: Fazim 50 mg Capsule, CLOFZIMIN® 100 MGBrotizolam
go.drugbank.com/drugs/DB09017ApprovedWithdrawnBrotizolam is indicated for 2-4 weeks of treatment for severe or debilitating insomnia. … Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog. It demonstrates anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant effects.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesInternational brands: Brotizolam M