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Reserpine
go.drugbank.com/drugs/DB00206ApprovedWithdrawnIt has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. … An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Mixtures: Ser-Ap-Es, Ser-AP-ES TabCategories: P-glycoprotein inducers, P-glycoprotein inhibitorsSacubitril
go.drugbank.com/drugs/DB09292ApprovedInvestigationalSacubitril's active metabolite, LBQ657 inhibits neprilysin, a neutral endopeptidase that would typically cleave natiuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide ( … Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection
Dequalinium
go.drugbank.com/drugs/DB04209Approved[A249255] It is a quaternary ammonium compound,[L42190] as it consists of an amphipathic cation with two aminoquinaldinium rings at both ends of a long hydrophobic hydrocarbon chain. … [A249255] First used as an antiseptic and disinfectant in the 1950s, dequalinium is still found in various OTC products to treat conditions of oral infections and inflammation.
Vandetanib
go.drugbank.com/drugs/DB05294ApprovedInvestigationalVandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesLepirudin
go.drugbank.com/drugs/DB00001ApprovedWithdrawnLepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor. … [A246609] Lepirudin is used as an anticoagulant in patients with heparin-induced thrombocytopenia (HIT), an immune reaction associated with a high risk of thromboembolic complications.
Cannabidiol
go.drugbank.com/drugs/DB09061ApprovedInvestigationalCBD is currently available in Canada within a 1:1 formulation with tetrahydrocannbinol (THC) (as the formulation known as "nabiximols") as the brand name product Sativex. … (such as THC) are limited by their psychomimetic effects such as changes to mood, memory, and anxiety[A32469].
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP1A2 InducersSynonyms: (−)-trans-2-p-mentha-1,8-dien-3-yl-5-pentylresorcinolPumactant
go.drugbank.com/drugs/DB04955ExperimentalIt is a unique formulation of the naturally occurring phospholipids Dipalmitoylphosphatidycholine (DPPC) and Phosphatidyl Glycerol (PG). … Pumactant is a synthetic surfactant used for treating respiratory distress syndrome in neonates.
Indomethacin
go.drugbank.com/drugs/DB00328ApprovedInvestigationalNSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole … Intravenous indometacin is administered to close a hemodynamically significant patent ductus arteriosus, as indicated by clinical evidence, in premature infants.
Synonyms: 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acidCategories: P-glycoprotein inhibitors, P-glycoprotein substratesNaltrexone
go.drugbank.com/drugs/DB00704ApprovedInvestigationalVet approvedIt is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction.
Guaiacol
go.drugbank.com/drugs/DB11359ApprovedGuaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. … Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma.