Guaiacol

Identification

Generic Name
Guaiacol
DrugBank Accession Number
DB11359
Background

Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 124.139
Monoisotopic: 124.052429498
Chemical Formula
C7H8O2
Synonyms
  • 1-hydroxy-2-methoxybenzene
  • 2-methoxyl-4-vinylphenol
  • 2-methoxyphenol
  • Guaiacol
  • o-guaiacol
  • o-hydroxyanisole
  • o-Methoxyphenol
  • Pyrocatechol monomethyl ether
  • Pyroguaiac acid
External IDs
  • Fema no. 2532
  • NSC-3815

Pharmacology

Indication

It is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a potent scavenger of reactive oxygen radicals and its radical scavenging activity may be associated with its effect on cell proliferation.

Pharmacology
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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
USerum albuminNot AvailableHumans
Absorption

In rats, guaiacol is rapidly absorbed, being present in the blood 5 minutes after oral administration, and reaching its peak plasma concentration in about 10 minutes. Its elimination from the blood is usually as rapid.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Excreted by rabbits in combined form with sulfate (15%) and glucuronic acid (72%).

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Guaiacol carbonateQ71XPQ6R29553-17-3ORUJFMPWKPVXLZ-UHFFFAOYSA-N
Guaiacol hydrochlorideNot AvailableNot AvailableAXHWIVKRWPJSOF-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Analgesic BalmGuaiacol (1.25 %) + Eucalyptus oil (2.5 %) + Levomenthol (3.12 %) + Methyl salicylate (25 %)OintmentTopicalStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1965-12-312000-07-27Canada flag
BRONCHODERMINE UNGUENTOGuaiacol (3.03 g) + Camphor (1.5 g) + Eucalyptus oil (1.5 g) + Levomenthol (0.5 g)OintmentTopicalLABORATORIO FRANCO COLOMBIANO - LAFRANCOL S.A.S.2006-11-10Not applicableColombia flag
Creo-rectal Adultes/adultsGuaiacol carbonate (600 mg) + Camphor (5 mg) + Diphenylpyraline hydrochloride (1.5 mg)SuppositoryRectalLaboratoires Confab Inc1951-12-31Not applicableCanada flag
Creo-rectal Enfants/childrenGuaiacol carbonate (200 mg) + Camphor (2 mg) + Diphenylpyraline hydrochloride (0.5 mg)SuppositoryRectalLaboratoires Confab Inc1951-12-31Not applicableCanada flag
Creo-rectal NourrissonGuaiacol carbonate (100 mg) + Camphor (1 mg) + Diphenylpyraline hydrochloride (0.25 mg)SuppositoryRectalSandoz Canada Incorporated1951-12-312012-11-02Canada flag
Demo Cineol InjGuaiacol (167 mg / mL) + Camphor (20 mg / mL) + Eucalyptol (184 mg / mL)LiquidIntramuscularSabex Inc1951-12-311998-08-12Canada flag
Demo-cineol Adultes/adultsGuaiacol carbonate (200 mg) + Guaiacol (180 mg) + Camphor (40 mg) + Eucalyptol (370 mg)SuppositoryRectalSandoz Canada Incorporated1986-12-31Not applicableCanada flag
Demo-cineol Adultes/adultsGuaiacol carbonate (200 mg) + Guaiacol (180 mg) + Camphor (40 mg) + Eucalyptol (370 mg)SuppositoryRectalSandoz Canada Incorporated1986-12-31Not applicableCanada flag
Demo-cineol Enfants/childrenGuaiacol carbonate (100 mg) + Guaiacol (90 mg) + Camphor (20 mg) + Eucalyptol (185 mg)SuppositoryRectalSandoz Canada Incorporated1977-12-31Not applicableCanada flag
Demo-cineol Enfants/childrenGuaiacol carbonate (100 mg) + Guaiacol (90 mg) + Camphor (20 mg) + Eucalyptol (185 mg)SuppositoryRectalSandoz Canada Incorporated1977-12-31Not applicableCanada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Dry SocketGuaiacol (0.0416 g/1g) + Eugenol (0.0416 g/1g)PasteDentalDentsply Llc, Professional Division, Trading As "Sultan Healthcare"1900-01-01Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as methoxyphenols. These are compounds containing a methoxy group attached to the benzene ring of a phenol moiety.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Phenols
Sub Class
Methoxyphenols
Direct Parent
Methoxyphenols
Alternative Parents
Phenoxy compounds / Methoxybenzenes / Anisoles / Alkyl aryl ethers / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids / Hydrocarbon derivatives
Substituents
1-hydroxy-2-unsubstituted benzenoid / 1-hydroxy-4-unsubstituted benzenoid / Alkyl aryl ether / Anisole / Aromatic homomonocyclic compound / Ether / Hydrocarbon derivative / Methoxybenzene / Methoxyphenol / Monocyclic benzene moiety
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
phenols, monomethoxybenzene (CHEBI:28591) / a guaiacol (CPD-400)
Affected organisms
Not Available

Chemical Identifiers

UNII
6JKA7MAH9C
CAS number
90-05-1
InChI Key
LHGVFZTZFXWLCP-UHFFFAOYSA-N
InChI
InChI=1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3
IUPAC Name
2-methoxyphenol
SMILES
COC1=C(O)C=CC=C1

References

General References
  1. Monograph [Link]
Human Metabolome Database
HMDB0001398
KEGG Drug
D00117
KEGG Compound
C01502
PubChem Compound
460
PubChem Substance
347827973
ChemSpider
447
BindingDB
50240369
RxNav
5031
ChEBI
28591
ChEMBL
CHEMBL13766
ZINC
ZINC000013512224
PDBe Ligand
JZ3
Wikipedia
Guaiacol
PDB Entries
3ht9 / 4a6z / 4a78 / 4g05 / 4qoq / 5ncb / 6hqk / 6hql / 6hqm / 6hqn
show 6 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3TerminatedTreatmentCough1
3Unknown StatusTreatmentCough1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
OintmentTopical
LiquidIntramuscular
SuppositoryRectal
LiquidDental
PasteDental
SolutionTopical
SyrupOral
LozengeOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility67.4 mg/mLALOGPS
logP1.32ALOGPS
logP1.51ChemAxon
logS-0.27ALOGPS
pKa (Strongest Acidic)9.98ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.46 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity34.5 m3·mol-1ChemAxon
Polarizability12.69 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-0a4i-6900000000-49cb804087a42b1d1a22
GC-MS Spectrum - EI-BGC-MSsplash10-0ab9-5900000000-b580cbc25d4176ce3894
GC-MS Spectrum - EI-BGC-MSsplash10-0pir-9700000000-f1436b3de82cff342b65
GC-MS Spectrum - EI-BGC-MSsplash10-05fr-4900000000-c09a31d9523d2eab5598
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-014i-0900000000-283fdedfda9e853e0cac
Mass Spectrum (Electron Ionization)MSsplash10-0ac0-9800000000-5e89a9881e848e1b6c90
MS/MS Spectrum - EI-B (HITACHI RMU-6E) , PositiveLC-MS/MSsplash10-0a4i-6900000000-49cb804087a42b1d1a22
MS/MS Spectrum - EI-B (HITACHI RMU-6L) , PositiveLC-MS/MSsplash10-0ab9-5900000000-b580cbc25d4176ce3894
MS/MS Spectrum - EI-B (HITACHI M-80B) , PositiveLC-MS/MSsplash10-0pir-9700000000-12606badb77d4257635d
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-0900000000-6b7a2fdf4e9a28ec6045
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-2900000000-ff014b7b55a5237cf91e
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-9100000000-8785b2e2d86c6294a754
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-0900000000-8856c60866e810389af7
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-1900000000-8db14d5e5710471f76a7
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-9400000000-bc0d3592d62ec26dad6f
1H NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Targets

Drugtargets2
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Ogata N, Shibata T: Binding of alkyl- and alkoxy-substituted simple phenolic compounds to human serum proteins. Res Commun Mol Pathol Pharmacol. 2000;107(1-2):167-73. [Article]

Drug created on December 03, 2015 16:52 / Updated on February 21, 2021 18:53