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Zomepirac
go.drugbank.com/drugs/DB04828ApprovedWithdrawnZomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid reactions. The manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983.
Synonyms: 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acidCategories: Non COX-2 selective NSAIDS, Cytochrome P-450 SubstratesZimelidine
go.drugbank.com/drugs/DB04832ApprovedWithdrawnZimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving
Categories: P-glycoprotein inhibitors, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSynonyms: (Z)-3-(4'-Bromophenyl)-3-(3''-pyridyl)dimethylallylamine, (Z)-zimelidineAmineptine
go.drugbank.com/drugs/DB04836ApprovedIllicitWithdrawnThe Food and Drug Administration suspended the marketing authorisation for Survector in 1999 and France withdrew it from the market, however several developing countries continued to produce it up until 2005.
Cyclandelate
go.drugbank.com/drugs/DB04838ApprovedWithdrawnA direct-acting smooth muscle relaxant used to dilate blood vessels. It may cause gastrointestinal distress and tachycardia. … Cyclandelate is not approved for use in the U.S. or Canada, but is approved in various European countries.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDebrisoquine
go.drugbank.com/drugs/DB04840ApprovedIt is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. … They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesFlunarizine
go.drugbank.com/drugs/DB04841ApprovedInvestigationalFlunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazineRoxadustat
go.drugbank.com/drugs/DB04847ApprovedInvestigationalRoxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. … [A245393] Roxadustat was first approved by the European Commission in August 2021.[L40323]
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingZanapezil
go.drugbank.com/drugs/DB04859ExperimentalZanapezil (TAK-147) is a selective acetylcholine (ACh) esterase inhibitor under investigation as a drug for Alzheimer's disease (AD) treatment.
Categories: Heterocyclic Compounds, 2-RingIsatoribine
go.drugbank.com/drugs/DB04860ExperimentalIsatoribine is a selective agonist of TLR7.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 7-Deaza-7-thia-8-oxoguanosine, 7-Thia-8-oxoguanosineNebivolol
go.drugbank.com/drugs/DB04861ApprovedInvestigationalNebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. … [A182579] Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol].
Mixtures: AMLONEB 5 MG/5 MG TABLET, 30 ADET, AMLONEB 5 MG/5 MG TABLET, 90 ADETCategories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor Agonists