Zimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving many organs... Additionally, zimelidine was charged to cause an increase in suicidal ideation and/or attempts among depressive patients.
- Mechanism
- Curator reviewed
The antidepressant actions of zimelidine are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Zimelidine blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
- Primary indication
- For the treatment of depression.Curator reviewed
- Formula / weight
- C16H17BrN2 · 317.23 g/mol (avg)
- Also known as
- Zimeldine
Resolves to
OYPPVKRFBIWMSX-SXGWCWSVSA-NSMILESCN(C)C\C=C(\C1=CC=C(Br)C=C1)C1=CC=CN=C1What you can answer from here — as of October 01, 2026
Which drugs share a target with Zimelidine, and which of those have an active Phase 3 trial?
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