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Displaying results 1211 - 1220 of 10000 in total
  1. Target

    Mas-related G protein-coupled receptor member X2

    go.drugbank.com/bio_entities/BE0018408
    TargetHumans

    Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:22069323, PubMed:25517090, PubMed:28288109 … Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37

    Polypeptides: Mas-related G protein-coupled receptor member X2Function: C-C chemokine receptor activity
  2. Drug

    Rosin

    go.drugbank.com/drugs/DB11165
    Approved

    Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. It is prepared from heating fresh liquid resin to vaporize the volatile liquid terpene components.

    Mixtures: Tincture Green, Tincture Green SoapCategories: Compounds used in a research, industrial, or household setting
  3. Indication

    Triple-Negative Breast Cancer

    go.drugbank.com/conditions/DBCOND0068542
    Drugs: Atezolizumab
    Synonyms: Breast Carcinoma That is Estrogen Receptor, Progesterone Receptor, and Her2 Negative
  4. Drug

    Apalutamide

    go.drugbank.com/drugs/DB11901
    ApprovedInvestigational

    It targets the AR ligand-binding domain and prevents AR nuclear translocation, DNA binding, and transcription of AR gene targets in prostate tumors [A31846]. … Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements [A31846]

    Categories: Androgen Receptor Inhibitors, MATE 1 InhibitorsProducts: ERLEADA ®TABLETAS RECUBIERTAS 60 MG
  5. Drug

    Arsthinol

    go.drugbank.com/drugs/DB08928
    Experimental

    Considered well tolerated when compared to other related trivalent organoarsenicals, arsthinol has even undergone recent studies as a potential anticancer agent. … It has since been demonstrated that the agent possesses activity against amoebas and yaws.

  6. Drug

    Aminopterin

    go.drugbank.com/drugs/DB08878
    ApprovedWithdrawn

    In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less toxic. Off label, aminopterin has also been used in the treatment of psoriasis.

    Categories: Heterocyclic Compounds, 2-RingSynonyms: N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid, 4-amino-4-deoxypteroylglutamate
  7. Drug

    Donislecel

    go.drugbank.com/drugs/DB17961
    Approved

    [L47196] Overall, 21 patients achieved insulin independence for a year or more, with 11 patients not needing insulin for 1 to 5 years and 10 patients for more than 5 years. … [L47166,L47196] The approval of donislecel was based on the safety and effectiveness evaluated in 2 clinical trials with 30 type 1 diabetic patients.

    Categories: Cellular and Gene Therapy
  8. Drug

    Pheniramine

    go.drugbank.com/drugs/DB01620
    Approved

    Pheniramine is a first-generation antihistamine in the alkylamine class, similar to [brompheniramine] and [chlorpheniramine]. … Pheniramine's use as an anti-allergy medication has largely been supplanted by second-generation antihistamines such as [cetirizine] and [loratadine].

    Mixtures: Opcon-A, Opcon-ACategories: Heterocyclic Compounds, 1-Ring
  9. Drug

    Rosiglitazone

    go.drugbank.com/drugs/DB00412
    ApprovedInvestigational

    Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. … This is the subject of a clinical trial currently underway.

    Categories: Peroxisome Proliferator Receptor gamma Agonist, Peroxisome Proliferator-activated Receptor ActivitySynonyms: (±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedione, (RS)-5-{4-[2-(Methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedion
  10. Drug

    Tobramycin

    go.drugbank.com/drugs/DB00684
    ApprovedInvestigational

    such as β-lactams and cephalosporins. … [A232294, A232299, L32739] However, tobramycin can also be administered intravenously and topically to treat a variety of infections caused by susceptible bacteria.

    Mixtures: TOBRAMISOL D®, GOTABIOTIC(R)F OFTALMICOCategories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index