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Displaying results 1221 - 1230 of 10000 in total
  1. Drug

    N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide

    go.drugbank.com/drugs/DB07812
    Experimental

    Synonyms: N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
  2. Drug

    (r)-2-(((3-cyclobutyl-5-(3,4,5-trifluorophenoxy)-3h-imidazo(4,5-b)pyridin-2-yl)methyl)amino)propanamide

    go.drugbank.com/drugs/DB33626
    Experimental

    Synonyms: (r)-2-(((3-cyclobutyl-5-(3,4,5-trifluorophenoxy)-3h-imidazo(4,5-b)pyridin-2-yl)methyl)amino)propanamide
  3. Drug

    P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate

    go.drugbank.com/drugs/DB03845
    Experimental

    Synonyms: P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate
  4. Drug

    Astemizole

    go.drugbank.com/drugs/DB00637
    ApprovedWithdrawn

    Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. … It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.

    Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexSynonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole, 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole
  5. Drug

    Depulfavirine

    go.drugbank.com/drugs/DB18890
    Investigational

    Depulfavirine is under investigation in clinical trial NCT05204394 (Study to Evaluate Efficacy and Safety of Switching to VM-1500A-LAI + 2nrtis From the 1st Line Standard of Care Therapy).

    Synonyms: 2-[4-Bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]-N-(2-chloro-4-sulfamoylphenyl)acetamide, Benzeneacetamide, N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoro-
  6. Drug

    Inavolisib

    go.drugbank.com/drugs/DB15275
    ApprovedInvestigational

    _PIK3CA_ is one of the most frequently mutated oncogenes, with the resulting mutated p110α protein it encodes playing a central role in tumor cell proliferation. … [A264563] Chemotherapeutic agents targeting the PI3K p110α catalytic subunit have shown antitumor activity and a manageable safety profile - some of which are in clinical use, like [alpelisib] - but preclinical

    Synonyms: (2S)-2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-D)(1,4)benzoxazepin-9-yl)amino)propanamide, propanamide, 2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-D)(1,4)benzoxazepin-9-yl)amino)-, (2S)-Categories: Cytochrome P-450 CYP2B6 Inducers, Heterocyclic Compounds, 1-Ring
  7. Drug

    Oxcarbazepine

    go.drugbank.com/drugs/DB00776
    ApprovedInvestigational

    - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine]. … [L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood

    Synonyms: 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamideCategories: P-glycoprotein inducers, P-glycoprotein substrates
  8. Drug

    Medroxyprogesterone acetate

    go.drugbank.com/drugs/DB00603
    ApprovedInvestigational

    Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. … [A14848] MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prevent pregnancy,

    Synonyms: (6α)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione, 6-alpha-Methyl-17-alpha-acetoxyprogesteroneInternational brands: Depo-subq provera 104
  9. Drug

    Metronidazole benzoate

    go.drugbank.com/drugs/DB15759
    Investigational

    Synonyms: 2-(2-Methyl-5-nitroimidazol-1-yl)ethyl benzoateMixtures: METRONIDAZOL BENZOILO/ NIFUROXAZIDA 250MG + 200MG/5 ML SUSPENSION, DIARSET NX- M SUSPENSION
  10. Drug

    Aceclofenac

    go.drugbank.com/drugs/DB06736
    Approved

    It is a more commonly prescribed drug in Europe. … It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies [A19667, A19668, A19670].

    Mixtures: ZERODOL PCategories: Selective Cyclooxygenase 2 Inhibitors (NSAIDs), Cytochrome P-450 Substrates