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Ichthammol
go.drugbank.com/drugs/DB11341ApprovedIt is an ammonium salt of dark sulfonated shale oil (bituminous schists) produced via distillation of the oil followed by sulfonation and neutralization.
Tisotumab vedotin
go.drugbank.com/drugs/DB16732ApprovedInvestigationala tissue factor-directed antibody-drug conjugate (ADC) comprised of an anti-tissue factor (TF) human IgG1-kappa antibody conjugated to monomethyl auristatin E (MMAE), a microtubule-disrupting agent, via
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesIsatuximab
go.drugbank.com/drugs/DB14811ApprovedInvestigationalIsatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line. Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and tw...
Testosterone undecanoate
go.drugbank.com/drugs/DB13946ApprovedInvestigational[L35970] It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesRosiglitazone
go.drugbank.com/drugs/DB00412ApprovedInvestigationalRecent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. … Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ
Synonyms: (±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedioneCategories: Peroxisome Proliferator Receptor gamma Agonist, Peroxisome Proliferator-activated Receptor ActivityLysine
go.drugbank.com/drugs/DB00123ApprovedInvestigationalNutraceuticalLysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, a...
Mixtures: Aminosyn-PF, Aminosyn-PFUlipristal
go.drugbank.com/drugs/DB08867ApprovedInvestigationalA recent systematic review proclaimed that the majority of available evidence demonstrates an inhibitory effect on ovulation rather than a post-fertilization effect on the endometrium, which has been heavily … It also binds to glucocorticoid receptor, however compared to mifepristone (a progesterone receptor antagonist), ulipristal is more tolerable and has lower glucocorticoid activity and better binding affinity
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCamphor
go.drugbank.com/drugs/DB01744ApprovedInvestigationalWithdrawnCamphor is a bicyclic monoterpene ketone found widely in plants, especially Cinnamomum camphora. It is used topically as a skin antipruritic and as an anti-infective agent. When ingested, camphor has a rapid onset of toxic effects, and c...
Mixtures: VIVA Patch, VIVA PatchGamma-aminobutyric acid type B receptor subunit 1
go.drugbank.com/bio_entities/BE0000217TargetHumansLigand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase ( … Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating
Polypeptides: Gamma-aminobutyric acid type B receptor subunit 1Synonyms: GABA-B receptor 1Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
go.drugbank.com/bio_entities/BE0000628TargetHumansLow affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells
Polypeptides: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha