Explore a selection of our essential drug information below, or:
Identification
- Summary
Camphor is a compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.
- Brand Names
- Fast Freeze
- Generic Name
- Camphor
- DrugBank Accession Number
- DB01744
- Background
Camphor is a bicyclic monoterpene ketone found widely in plants, especially Cinnamomum camphora. It is used topically as a skin antipruritic and as an anti-infective agent. When ingested, camphor has a rapid onset of toxic effects, and camphorated oil is the product most often responsible for its toxicity. The FDA ruled that camphorated oil could not be marketed in the United States and that no product could contain a concentration higher than 11%. It appears in the list of drug products withdrawn or removed from the market for safety or effectiveness.1,2 However, camphor can be found in several nonprescription medications at lower concentrations.1
- Type
- Small Molecule
- Groups
- Approved, Withdrawn
- Structure
Structure for Camphor (DB01744)
- Weight
- Average: 152.2334
Monoisotopic: 152.120115134 - Chemical Formula
- C10H16O
- Synonyms
- (+)-bornan-2-one
- (+)-Camphor
- (1R,4R)-camphor
- (1R)-(+)-camphor
- (R)-(+)-camphor
- (R)-camphor
- Camphor (natural)
- Camphor D-form
- Camphor oil
- Camphor(D)
- Camphora
- D-Camphor
- Dextrocamphor
- Natural camphor
- External IDs
- FEMA NO. 2230
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Arthritis ••• ••• Symptomatic treatment of Backache ••• ••• Symptomatic treatment of Bruises ••• ••• Symptomatic treatment of Common cold ••• ••• Used in combination to treat Inflammatory reaction caused by insect bites Combination Product in combination with: Eucalyptus oil (DB11114) ••• ••• •••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism ATransient receptor potential cation channel subfamily V member 1 agonistactivatorHumans ATransient receptor potential cation channel subfamily V member 3 agonistactivatorHumans ATransient receptor potential cation channel subfamily A member 1 inhibitorHumans ATransient receptor potential cation channel subfamily M member 8 activatorHumans UCamphor 5-monooxygenase substratePseudomonas putida - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
Hover over products below to view reaction partners
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 365 Medicated Lip Balm Stick 0.0578 g/4.25g Topical Whole Foods Market, Inc. 2019-06-13 Not applicable US 
amoray premium Vaporizing Inhaler Liquid 13 mg/1 Nasal Ningbo Pulisi Daily Chemical Products 2016-03-31 Not applicable US ArthroNEO Spray 0.5 g/100g Topical Hakimian Global LLC 2021-10-27 Not applicable US ArthroNEO Spray 0.5 g/100g Topical Likasso LTD 2021-10-27 Not applicable US Band-aid Brand Anti-itch Gel Gel 0.50 % Topical Johnson & Johnson 2001-06-01 2009-08-06 Canada 
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Aching Head Rub Camphor (3.09 g/100g) + Menthol (2.55 g/100g) Ointment Topical Little Moon Essentials 2016-09-26 Not applicable US After Bite Natural Camphor (10 mg/1g) + Colloidal oatmeal (100 mg/1g) Salve Topical Adventure Ready Brands 2022-04-01 Not applicable US AIM Muscle Pain Relief Cream Camphor (2.5 g/100g) + Menthol (1.5 g/100g) + Methyl salicylate (10 g/100g) Cream Topical Laboratorios Bremer, S.A. 2018-01-04 2019-12-19 US Air Salonpas Camphor (3.00 mg/100mL) + Menthol (3.20 mg/100mL) + Methyl salicylate (1.75 mg/100mL) Aerosol, spray Percutaneous; Topical; Transdermal Hisamitsu Pharmaceutical Co., Inc. 1997-09-03 2014-04-30 US Amoray Care Chest Rub Camphor (4.7 g/113g) + Eucalyptus oil (1 g/113g) + Menthol (2 g/113g) Gel Topical MY IMPORT USA INC 2010-03-10 2017-02-10 US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image AMULDY SPORTS gel Camphor (0.05 g/100mL) + Menthol (2.5 g/100mL) + Methyl salicylate (0.3 g/100mL) + Salicylic acid (0.03 g/100mL) Liquid Topical Lydia Co., Ltd. 2020-04-24 Not applicable US Camphomex Camphor (3.6 mg/1mL) + Histamine (0.03 mg/1mL) + Menthol (12 mg/1mL) Spray Topical 1st Class Pharmaceuticals 2014-03-24 2016-01-15 US Chun Gi So Camphor (1 g/100g) + Menthol (1 g/100g) Cream Topical CHO WELL GF 2019-11-17 Not applicable US Ddsgen Camphor (1 g/100g) + Menthol (1 g/100g) Cream Topical The Times Co., Ltd. 2019-05-11 Not applicable US Kaydia Patch Camphor (3 g/100g) + Cannabidiol (0.15 g/100g) + Levomenthol (1 g/100g) Patch Topical Strong Current Enterprises Limited 2020-05-02 Not applicable US
Categories
- ATC Codes
- C01EB02 — Camphora
- Drug Categories
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antipruritics and Local Anesthetics
- Basic Lotions and Liniments
- Bicyclic Monoterpenes
- Biological Products
- Bornanes
- Bridged-Ring Compounds
- Cardiac Therapy
- Complex Mixtures
- Ketones
- Monoterpenes
- Norbornanes
- Pharmaceutical Preparations
- Plant Extracts
- Plant Preparations
- Terpenes
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as bicyclic monoterpenoids. These are monoterpenoids containing exactly 2 rings, which are fused to each other.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Prenol lipids
- Sub Class
- Monoterpenoids
- Direct Parent
- Bicyclic monoterpenoids
- Alternative Parents
- Ketones / Organic oxides / Hydrocarbon derivatives
- Substituents
- Aliphatic homopolycyclic compound / Bicyclic monoterpenoid / Bornane monoterpenoid / Carbonyl group / Hydrocarbon derivative / Ketone / Organic oxide / Organic oxygen compound / Organooxygen compound
- Molecular Framework
- Aliphatic homopolycyclic compounds
- External Descriptors
- camphor (CHEBI:15396)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- N20HL7Q941
- CAS number
- 464-49-3
- InChI Key
- DSSYKIVIOFKYAU-XCBNKYQSSA-N
- InChI
- InChI=1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3/t7-,10+/m1/s1
- IUPAC Name
- (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
- SMILES
- [H][C@@]12CC[C@@](C)(C(=O)C1)C2(C)C
References
- Synthesis Reference
Gerard Lang, Serge Forestier, Alain LaGrange, "Derivatives of 3-benzylidene camphor, process for their preparation and their use as protective agents against UV rays and as medicaments." U.S. Patent US4710584, issued January, 1984.
US4710584- General References
- Love JN, Sammon M, Smereck J: Are one or two dangerous? Camphor exposure in toddlers. J Emerg Med. 2004 Jul;27(1):49-54. doi: 10.1016/j.jemermed.2004.02.010. [Article]
- Code of Federal Regulations 216.24: Drug products withdrawn or removed from the market for reasons of safety or effectiveness. [Link]
- External Links
- Human Metabolome Database
- HMDB0059838
- KEGG Drug
- D06392
- KEGG Compound
- C00808
- PubChem Compound
- 159055
- PubChem Substance
- 46508429
- ChemSpider
- 139902
- BindingDB
- 36263
- 1298738
- ChEBI
- 15396
- ChEMBL
- CHEMBL504760
- ZINC
- ZINC000000967520
- PharmGKB
- PA448759
- PDBe Ligand
- CAM
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Camphor
- PDB Entries
- 1akd / 1dz4 / 1dz6 / 1dz8 / 1dz9 / 1geb / 1iwi / 1iwj / 1o76 / 1t85 … show 64 more
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Diagnostic Dermatitis, Photocontact 1 somestatus stop reason just information to hide Not Available Completed Treatment Hypopituitarism 1 somestatus stop reason just information to hide 3 Unknown Status Treatment Cough 1 somestatus stop reason just information to hide 1 Completed Treatment Common Cold 1 somestatus stop reason just information to hide 0 Not Yet Recruiting Basic Science Aging 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- DSHealthcare Inc.
- Dosage Forms
Form Route Strength Stick Topical 0.0578 g/4.25g Ointment Nasal Aerosol, spray Percutaneous; Topical; Transdermal Powder Cutaneous Liquid Nasal 13 mg/1 Liquid Buccal Liquid Oral Spray Topical 0.5 g/100g Solution / drops Auricular (otic) Spray Topical Liquid Respiratory (inhalation) 6 % Gel Topical 0.50 % Solution Topical 0.5 % Oil Percutaneous; Topical; Transdermal Ointment Topical 12.4 mg/1g Ointment Respiratory (inhalation); Topical Gel Topical Cream Topical 0.15 g/100g Ointment Topical 10 g/100g Liquid Oral; Topical 10 % Liquid Topical 10 g / 100 mL Liquid Topical 10 % Liquid Topical 100 mg / mL Liquid Topical 20 % Liquid Topical 200 mg / g Liquid Topical 200 g / 1 kg Ointment Topical 20 % Tincture Oral Liniment Topical Solution Topical 10 % Solution Topical Solution Cutaneous Cream Topical 3 g/100g Cream Topical 5 g/100g Oil Topical 3 g/100mL Stick Topical Plaster Topical 1 g/100g Patch Topical 13.875 mg/1h Jelly Topical Oil Patch Topical Ointment Topical 2 % w/w Cream Topical 2 g/100mL Oil Topical 1.1 g/100g Ointment Topical 2.576 g/60mL Liquid Intramuscular Suppository Rectal Cream Topical 3 g/100mL Lotion Topical Lotion Topical 0.005 g/1mL Liquid Topical 7.79 g/100mL Aerosol, spray Topical Patch Cutaneous Kit Topical Liquid Respiratory (inhalation) 1 %w/v Swab Topical 0.15 mg/1g Ointment Topical 3.0 g/100g Spray Topical 3.1 g/100mL Plaster Cream Topical 0.5 g/100mL Lotion Cutaneous Plaster Transdermal Lotion Topical 32 g/1000g Cream Topical 30 mg / g Patch Topical 22.5 mg/1 Gel Topical 4 g/100mL Ointment Topical Liquid Respiratory (inhalation) Gel Topical 50 mg/1mL Lotion Topical 0.7 g/100mL Cream Topical 30 mg/1000mg Aerosol Topical Salve Topical Oil Topical 6 g/4576mL Liniment Percutaneous; Transdermal 1 g/3500mL Liniment Percutaneous; Transdermal Solution Oil Topical 3 mL/100mL Cream Topical 1.5 g/50g Spray Topical 3 g/100mL Liquid Topical 3.1 g/100g Liquid Topical 3.1 g/100mL Solution Topical Tablet Oral Liquid Topical .0225 g/.75mL Cream Topical 1 g/100g Aerosol, spray Topical 1.5 g/100mL Lotion Topical 1.5 g/100g Patch Topical 280 mg/1 Gel Topical 1.5 g/100g Liniment Topical 3.5 g/100mL Cream Topical 3.3 g/100g Kit; patch Topical Cream Topical 2 g/100g Liquid Topical 100 mg/1mL Oil Topical Cream Topical Spray Cutaneous Ointment Topical 1 g/100g Cream Topical 13 g/100g Solution Topical 2.8 % w/w Spray Topical 1 mL/30mL Liquid Oral; Topical 10 g / 100 mL Liquid Topical Powder Topical Liquid Topical 1 mg/1mL Patch Topical 0.1 g/100g Ointment Topical 1.344 g/28g Patch Transdermal Plaster Cutaneous Plaster Topical Poultice Transdermal Liquid Respiratory (inhalation) 62 mg/1mL Ointment Cutaneous Solution Intrasinal; Respiratory (inhalation) Solution Nasal Stick Nasal Inhalant Nasal Ointment Topical 5 % Cream 10 mg Liquid Ophthalmic Plaster Transdermal 3.1 g/1 Ointment Liquid Dental Solution Oral Emulsion Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 180 °C PhysProp boiling point (°C) 204 °C PhysProp water solubility 1600 mg/L (at 25 °C) YALKOWSKY,SH & HE,Y (2003) logP 2.38 DAYLIGHT (1999) - Predicted Properties
Property Value Source Water Solubility 0.88 mg/mL ALOGPS logP 2.85 ALOGPS logP 2.55 Chemaxon logS -2.2 ALOGPS pKa (Strongest Basic) -7.5 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 17.07 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 44.49 m3·mol-1 Chemaxon Polarizability 17.74 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9971 Blood Brain Barrier + 0.9836 Caco-2 permeable + 0.8084 P-glycoprotein substrate Non-substrate 0.5868 P-glycoprotein inhibitor I Non-inhibitor 0.639 P-glycoprotein inhibitor II Non-inhibitor 0.9104 Renal organic cation transporter Non-inhibitor 0.8103 CYP450 2C9 substrate Non-substrate 0.823 CYP450 2D6 substrate Non-substrate 0.8379 CYP450 3A4 substrate Substrate 0.6692 CYP450 1A2 substrate Non-inhibitor 0.8876 CYP450 2C9 inhibitor Non-inhibitor 0.9088 CYP450 2D6 inhibitor Non-inhibitor 0.9696 CYP450 2C19 inhibitor Non-inhibitor 0.9313 CYP450 3A4 inhibitor Non-inhibitor 0.9583 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.978 Ames test Non AMES toxic 0.9133 Carcinogenicity Non-carcinogens 0.8235 Biodegradation Not ready biodegradable 0.6872 Rat acute toxicity 1.6328 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.913 hERG inhibition (predictor II) Non-inhibitor 0.8076
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 131.1976868 predictedDarkChem Lite v0.1.0 [M-H]- 131.2102868 predictedDarkChem Lite v0.1.0 [M-H]- 131.3263868 predictedDarkChem Lite v0.1.0 [M-H]- 131.1880868 predictedDarkChem Lite v0.1.0 [M-H]- 140.105 predictedDeepCCS 1.0 (2019) [M+H]+ 131.6908868 predictedDarkChem Lite v0.1.0 [M+H]+ 131.4797868 predictedDarkChem Lite v0.1.0 [M+H]+ 131.5289868 predictedDarkChem Lite v0.1.0 [M+H]+ 131.5985868 predictedDarkChem Lite v0.1.0 [M+H]+ 142.23589 predictedDeepCCS 1.0 (2019) [M+Na]+ 131.4667868 predictedDarkChem Lite v0.1.0 [M+Na]+ 131.4058868 predictedDarkChem Lite v0.1.0 [M+Na]+ 131.4706868 predictedDarkChem Lite v0.1.0 [M+Na]+ 131.4826868 predictedDarkChem Lite v0.1.0 [M+Na]+ 148.1484 predictedDeepCCS 1.0 (2019)
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- AgonistActivator
- General Function
- Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis
- Specific Function
- ATP binding
- Gene Name
- TRPV1
- Uniprot ID
- Q8NER1
- Uniprot Name
- Transient receptor potential cation channel subfamily V member 1
- Molecular Weight
- 94955.33 Da
References
- Xu H, Blair NT, Clapham DE: Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci. 2005 Sep 28;25(39):8924-37. doi: 10.1523/JNEUROSCI.2574-05.2005. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- AgonistActivator
- General Function
- Receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen)
- Specific Function
- calcium channel activity
- Gene Name
- TRPV3
- Uniprot ID
- Q8NET8
- Uniprot Name
- Transient receptor potential cation channel subfamily V member 3
- Molecular Weight
- 90635.115 Da
References
- Xu H, Blair NT, Clapham DE: Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci. 2005 Sep 28;25(39):8924-37. doi: 10.1523/JNEUROSCI.2574-05.2005. [Article]
- Sherkheli MA, Vogt-Eisele AK, Weber K, Hatt H: Camphor modulates TRPV3 cation channels activity by interacting with critical pore-region cysteine residues. Pak J Pharm Sci. 2013 May;26(3):431-8. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity)
- Specific Function
- calcium channel activity
- Gene Name
- TRPA1
- Uniprot ID
- O75762
- Uniprot Name
- Transient receptor potential cation channel subfamily A member 1
- Molecular Weight
- 127499.88 Da
References
- Xu H, Blair NT, Clapham DE: Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci. 2005 Sep 28;25(39):8924-37. doi: 10.1523/JNEUROSCI.2574-05.2005. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Activator
- General Function
- Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel
- Specific Function
- calcium channel activity
- Gene Name
- TRPM8
- Uniprot ID
- Q7Z2W7
- Uniprot Name
- Transient receptor potential cation channel subfamily M member 8
- Molecular Weight
- 127684.035 Da
References
- Selescu T, Ciobanu AC, Dobre C, Reid G, Babes A: Camphor activates and sensitizes transient receptor potential melastatin 8 (TRPM8) to cooling and icilin. Chem Senses. 2013 Sep;38(7):563-75. doi: 10.1093/chemse/bjt027. Epub 2013 Jul 4. [Article]
- Kind
- Protein
- Organism
- Pseudomonas putida
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Involved in a camphor oxidation system.
- Specific Function
- camphor 5-monooxygenase activity
- Gene Name
- camC
- Uniprot ID
- P00183
- Uniprot Name
- Camphor 5-monooxygenase
- Molecular Weight
- 46668.8 Da
References
- Balaraman P, Plettner E: Chemotaxis by Pseudomonas putida (ATCC 17453) towards camphor involves cytochrome P450cam (CYP101A1). Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):304-312. doi: 10.1016/j.bbagen.2018.10.018. Epub 2018 Nov 1. [Article]
- Kammoonah S, Prasad B, Balaraman P, Mundhada H, Schwaneberg U, Plettner E: Selecting of a cytochrome P450cam SeSaM library with 3-chloroindole and endosulfan - Identification of mutants that dehalogenate 3-chloroindole. Biochim Biophys Acta Proteins Proteom. 2018 Jan;1866(1):68-79. doi: 10.1016/j.bbapap.2017.09.006. Epub 2017 Sep 18. [Article]
Drug created at June 13, 2005 13:24 / Updated at October 07, 2024 13:58