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Selumetinib
go.drugbank.com/drugs/DB11689ApprovedInvestigational[A193533] Following its initial FDA approval on April 10, 2020,[L49991] and Health Canada approval on August 23, 2022,[L49986] the regulatory landscape has evolved. … Most recently, on November 20, 2025, the FDA expanded this indication to include adults [L53881]
Categories: Heterocyclic Compounds, 2-Ring, Mitogen-Activated Protein Kinase Kinase 2 InhibitorsProducts: Koselugo Hard Capsules 10 mg, Koselugo Hard Capsules 25 mgSerine/threonine-protein kinase 24
go.drugbank.com/bio_entities/BE0009383TargetHumansSerine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JN...
Polypeptides: Serine/threonine-protein kinase 24C-C motif chemokine 24
go.drugbank.com/bio_entities/BE0011045TargetHumansIs a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line (PubMed:9104803, PubMed:9365122). Binds to CCR3 (PubMed:9104803, PubMed:9365122)
Polypeptides: C-C motif chemokine 24Triazolam
go.drugbank.com/drugs/DB00897ApprovedInvestigationalWithdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions. This drug continues to be available in the U.S. … Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: TRIAZOLAM EG, Halcion 0,25 mg - TablettenSodium oxybate
go.drugbank.com/drugs/DB09072ApprovedInvestigational[L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmitter [A251445] and a metabolite of the inhibitory neurotransmitter GABA. … in May 2023.
Products: Natriumoxybat Kalceks 500 mg/ml Lösung zum Einnehmen, Natriumoxybat neuraxpharm 500 mg/ml Lösung zum EinnehmenCarbidopa
go.drugbank.com/drugs/DB00190ApprovedInvestigationalIt potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier. … therapy developed by Mayne Pharma in 1992.
Synonyms: L-3-(3,4-dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acidMixtures: LEVO/CA/EN 100/25/200 STD, LEV/CAR/EN AL200/50/200Alpha-1-proteinase inhibitor
go.drugbank.com/drugs/DB00058ApprovedInvestigationalHuman alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
Synonyms: 122320-05-2, Alpha-1 MPProducts: PROLASTIN C 1000 MG IV İNFÜZYON İÇİN LİYOFİLİZE TOZ İÇEREN FLAKON, 1 ADET, Prolastin 1000 mg - Pulver und Lösungsmittel zur Herstellung einer InfusionslösungUrapidil
go.drugbank.com/drugs/DB12661InvestigationalUrapidil has been investigated for the treatment of Hypertension During Pre-Eclampsia.
Products: UPADİL 50 MG/10 ML IV ENJEKSİYONLUK ÇÖZELTİ, 5 ADET, EBRASEL 50 MG/10 ML I.V. ENJEKSIYONLUK ÇÖZELTI IÇEREN AMPUL, 5 ADETTranylcypromine
go.drugbank.com/drugs/DB00752ApprovedInvestigationalIt also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). … Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2A6 InhibitorsSynonyms: (1R*,2S*)-2-phenylcyclopropan-1-amine, (±)-trans-2-phenylcyclopropylamineDoxazosin
go.drugbank.com/drugs/DB00590ApprovedInvestigational[A180649] It is marketed by Pfizer and was initially approved by the FDA in 1990.[L7285] … Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension.
Synonyms: 1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin, 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazinInternational brands: Cardura-2, Cardura-4