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[4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone
go.drugbank.com/drugs/DB08778ExperimentalSynonyms: [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanoneEmivirine
go.drugbank.com/drugs/DB08188InvestigationalEmivirine has been used in trials studying the treatment of HIV Infections.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 6-benzyl-1-(ethoxymethyl)-5-(1-methylethyl)uracil, 1-(ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)pyrimidine-2,4(1H,3H)-dioneABSK-012
go.drugbank.com/drugs/DB18035ExperimentalSynonyms: N′-[5-Cyano-4-(cyclopropylamino)-2-pyridinyl]-N-[6-formyl-5-[(4-methyl-2-oxo-1-piperazinyl)methyl]-2-pyridinyl]-N-methylurea, Urea, N′-[5-cyano-4-(cyclopropylamino)-2-pyridinyl]-N-[6-formyl-5-[(4-methyl-2-oxo-1-piperazinyl)methyl]-2-pyridinyl]-N-methyl-Ixazomib
go.drugbank.com/drugs/DB09570ApprovedInvestigational[A264319] It was later approved by Health Canada on August 3, 2016,[L51239] and by the EMA on November 21, 2016. … [A7948] More than 99% of the drug compound is the R-enantiomer.[A264329] Ixazomib was approved by the FDA on November 20, 2015, making it the first oral proteasome inhibitor approved in the US.
Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: 2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diacetic acid, BORONIC ACID, B-((1R)-1-((2-((2,5-DICHLOROBENZOYL)AMINO)ACETYL)AMINO)-3-METHYLBUTYL)-AZD2066
go.drugbank.com/drugs/DB17078InvestigationalSynonyms: Pyridine, 4-(5-((1r)-1-(5-(3-chlorophenyl)-3-isoxazolyl)ethoxy)-4-methyl-4h-1,2,4-triazol-3-yl)-Categories: Receptor, Metabotropic Glutamate 5, antagonists & inhibitors, Heterocyclic Compounds, 1-RingCP-526423
go.drugbank.com/drugs/DB02089ExperimentalSynonyms: N,N'-[1,2-Ethanediylbis(oxy-2,1-ethanediyl)]bis(5-chloro-1H-indole-2-carboxamide), 1,2-bis(2-(5-chloroindole-2-carbonylamino)ethoxy)ethaneCategories: Heterocyclic Compounds, 2-RingMK-8189
go.drugbank.com/drugs/DB19153InvestigationalMK-8189 is under investigation in clinical trial NCT04624243 (Efficacy and Safety of MK-8189 in Participants With an Acute Episode of Schizophrenia (MK-8189-008)).
Categories: Heterocyclic Compounds, 1-RingSynonyms: 4-PYRIMIDINAMINE, 2-METHYL-6-(((1S,2S)-2-(5-METHYL-2-PYRIDINYL)CYCLOPROPYL)METHOXY)-N-((5-METHYL-1,3,4-THIADIAZOL-2-YL)METHYL)-Ulevostinag
go.drugbank.com/drugs/DB14721Investigationalfactor-kappa B (NF-kB) and interferon regulatory factor 3 (IRF3) in immune cells in the tumor microenvironment; this leads to the production of pro-inflammatory cytokines, including interferons (IFNs) … Upon intratumoral (IT) administration, STING agonist MK-1454 binds to STING and activates the STING pathway, which promotes IKK-related kinase TANK-binding kinase 1 (TBK1) signaling and activates nuclear
Synonyms: Cyclo((p3'r,2's)-2'-deoxy-2'-fluoro-p-thioadenylyl-(3'->5')-(p2'r)- 3'-deoxy-3'-fluoro-p-thioguanylyl-(2'->5')), Guanosine, (p(r))-2'-deoxy-2'-fluoro-5'-o-((r)-hydroxymercaptophosphinyl)-p-thio-.beta.-d-arabino-adenylyl-(3'->5')-3'-deoxy-3'-fluoro-, cyclic nucleotideCefepime
go.drugbank.com/drugs/DB01413ApprovedInvestigationalCefepime is a fourth-generation cephalosporin antibiotic developed in 1994. … [A249050] The popularity of its third-generation predecessors, its clinical efficacy, and the high prevalence of multidrug-resistant bacteria might be some of the factors leading to an increase in the
Categories: Heterocyclic Compounds, 2-RingSynonyms: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate4-Nitrocatechol sulfate
go.drugbank.com/drugs/DB01800ExperimentalSynonyms: 2-Hydroxy-5-nitrophenyl sulfate, 2-hydroxy-5-nitrophenyl hydrogen sulfate