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Displaying results 1251 - 1260 of 8696 in total
  1. Drug

    Alprazolam

    go.drugbank.com/drugs/DB00404
    ApprovedIllicitInvestigational

    [A18125] Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death. … Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  2. Drug

    Vusolimogene oderparepvec

    go.drugbank.com/drugs/DB23008
    ApprovedInvestigational

    on anti-PD-1 therapy. … on a PD-1-blocking antibody-based regimen.

  3. Drug

    Chloroquine

    go.drugbank.com/drugs/DB00608
    ApprovedInvestigationalVet approved

    Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. … [A192432] **The FDA emergency use authorization for [hydroxychloroquine] and chloroquine in the treatment of COVID-19 was revoked on 15 June 2020.

    Categories: Experimental Unapproved Treatments for COVID-19, P-glycoprotein inhibitors
  4. Drug

    Pipradrol

    go.drugbank.com/drugs/DB11584
    ApprovedWithdrawn

    Experimentation with the drug and its derivatives for recreational purposes has led to many cases of acute toxicity and has been linked to three fatalities. … Pipradrol was made illegal in many countries in 1970s because of its potential for abuse. It is currently classified under the Misuse of Drugs Act as a Class C substance [L2522].

    Categories: Psychostimulants, Agents Used for ADHD and Nootropics
  5. Drug

    IR-901

    go.drugbank.com/drugs/DB17932
    Experimental

    Synonyms: Human T-cell receptor (BV5S2)peptide
  6. Drug

    Tanfanercept

    go.drugbank.com/drugs/DB19142
    Investigational

    Tanfanercept is under investigation in clinical trial NCT06400589 (A Study to Evaluate the Efficacy and Safety of Tanfanercept (HL036) in Dry Eye Disease).

    Synonyms: 41-211-tumor necrosis factor receptor 1, L-methionyl-(l28>v,s52>m,h55>f,r57>p,h58>g,k121>n) tumor necrosis factor (tnf) binding protein variant 1 (tbp-1) with c-terminal extension by further 10 residues of the pro-protein, human, unglycosylated
  7. Drug

    Trametinib

    go.drugbank.com/drugs/DB08911
    ApprovedInvestigational

    [A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. … Originally developed by Japan Tobacco, trametinib was initially investigated for treating inflammation, but further studies for this indication were not pursued.[A258298]

    Categories: MAP Kinase, antagonists & inhibitors, MAP Kinase Kinase 1, antagonists & inhibitors
  8. Drug

    Dabrafenib

    go.drugbank.com/drugs/DB08912
    ApprovedInvestigational

    It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation.[L41955] It was also used for metastatic non-small cell lung cancer with the same mutation. … [L41955] In May 2018, Tafinlar (dabrafenib), in combination with Mekinist ([DB08911]), was approved to treat anaplastic thyroid cancer caused by an abnormal BRAF V600E gene.[L41955]

    Categories: P-glycoprotein substrates, Cytochrome P-450 CYP2B6 Inducers
  9. Indication

    Hormone Receptor Positive Breast Carcinoma

    go.drugbank.com/conditions/DBCOND0119681
    Drugs: Olaparib
    Synonyms: Hormone-receptor-positive Breast Cancer, Hormone Receptor-Positive Breast Carcinoma
  10. Drug

    Zinc chloride

    go.drugbank.com/drugs/DB14533
    Approved

    Zinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc levels and prevent deficiency syndromes.

    Mixtures: Orajel 4X Medicated PM For Toothache and Gum, PM Toothache ReliefCategories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use