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Gefapixant
go.drugbank.com/drugs/DB15097ApprovedIt has been estimated that 5-10% of adults globally suffer from chronic cough, which is defined as a cough lasting longer than eight weeks. A subset of these patients remain symptomatic despite thorough investigation and treatment, terme...
Categories: P-glycoprotein substratesFinerenone
go.drugbank.com/drugs/DB16165ApprovedInvestigationalFinerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart attacks, and hospitalization du...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesPaltusotine
go.drugbank.com/drugs/DB16277ApprovedInvestigationalPaltusotine is a selective somatostatin receptor agonist: It mimics the biological actions of endogenous somatostatin, which activates the somatostatin 2 receptor (SST2) to block the secretion of growth hormone (GH) and decreases the pro...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesMobocertinib
go.drugbank.com/drugs/DB16390ApprovedInvestigationalWithdrawnMobocertinib is a kinase inhibitor targeted against human epidermal growth factor receptor (EGFR). It is used specifically in the treatment of non-small cell lung cancer (NSCLC) caused by exon 20 insertion mutations in the EGFR gene, whi...
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsBenzgalantamine
go.drugbank.com/drugs/DB19353ApprovedInvestigationalBenzgalantamine is a prodrug of galantamine. Gastrointestinal adverse effects are the most frequently reported side effects in patients undergoing treatment with cholinesterase inhibitors, including galantamine, and are often a reason fo...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesHydrastine
go.drugbank.com/drugs/DB19354ExperimentalCategories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 SubstratesSetileuton
go.drugbank.com/drugs/DB19550InvestigationalSetileuton is a small molecule drug. The usage of the INN stem '-leuton' in the name indicates that Setileuton is a 5-lipo-oxygenase inhibitor, anti-inflammatory. Setileuton is under investigation in clinical trial NCT00404313 (The Effec...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesLefetamine
go.drugbank.com/drugs/DB19944ExperimentalLefetamine is a small molecule drug. Lefetamine has a monoisotopic molecular weight of 225.15 Da.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesMofarotene
go.drugbank.com/drugs/DB20333ExperimentalMofarotene is a small molecule drug. The usage of the INN stem '-arotene' in the name indicates that Mofarotene is a arotinoid derivative. Mofarotene has a monoisotopic molecular weight of 433.3 Da.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates