Search
Asunaprevir
go.drugbank.com/drugs/DB11586ApprovedWithdrawn[A32528] It was developed by Bristol-Myers Squibb Canada and approved by Health Canada on April 22, 2016. The commercialization of asunaprevir was cancelled one year later on October 16, 2017.[L1113] … It has been shown to have a very high efficacy in dual-combination regimens with daclatasvir in patients chronically infected with HCV genotype 1b.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: SUNVEPRA® 100MG CÁPSULAS BLANDASGalcanezumab
go.drugbank.com/drugs/DB14042ApprovedInvestigational[L42060] It is unknown if galcanezumab has an effect on pregnancy outcomes. A pregnancy exposure registry has been established to evaluate the safety of this drug in pregnant women.[L42060] … Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin gene-related peptide (CGRP).
Products: EMGALITY SOLUTION FOR INJECTION IN PRE-FILLED PEN 120 MG/ML, Pontevia 120 mg solution for injection in pre-filled pencAMP-dependent protein kinase (Protein kinase A)
go.drugbank.com/bio_entities/BE0010127TargetHumansby an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). … to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha
Polypeptides: cAMP-dependent protein kinase type I-alpha regulatory subunit, cAMP-dependent protein kinase type I-beta regulatory subunitStiripentol
go.drugbank.com/drugs/DB09118ApprovedInvestigational[A19739] Approved in the US, Canada, and Europe, stiripentol is used to treat seizures associated with Dravet syndrome.[L880,L42500,L42510] It is marketed under the brand name Diacomit. … Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.
Synonyms: 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol, 4,4-Dimethyl-1-((3,4-methylenedioxy)phenyl)-1-penten-3-olCategories: Cytochrome P-450 CYP1A2 Inducers, P-glycoprotein inhibitorsRosuvastatin
go.drugbank.com/drugs/DB01098ApprovedInvestigationalelevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. … [A181409,A1793] However, the results of the SATURN trial[A181427] concluded that despite this difference in potency, there was no difference in their effect on the progression of coronary atherosclerosis
Mixtures: ROSUVINA LEGRAND® E 10/40, ROSUVINA LEGRAND® E 10/20Categories: Drugs Used in Diabetes, Cytochrome P-450 SubstratesDocetaxel
go.drugbank.com/drugs/DB01248ApprovedInvestigational[A259676] Compared to paclitaxel, docetaxel is two times more potent as an inhibitor of microtubule depolymerization. Docetaxel binds to microtubules but does not interact with dimeric tubulin. … [L46466] Docetaxel was approved by the FDA in 1996 and is available in solution for injection for intravenous or parenteral administration.[A259676]
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol, N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxelProteasome activator complex subunit 1
go.drugbank.com/bio_entities/BE0008976TargetHumansThe PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
Synonyms: IGUP I-5111, Interferon gamma up-regulated I-5111 proteinNischarin
go.drugbank.com/bio_entities/BE0003580TargetHumansActs either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell surv...
Synonyms: I-1, I-1 receptor candidate proteinGliclazide
go.drugbank.com/drugs/DB01120ApprovedInvestigationalGliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). … Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%).
Categories: Drugs Used in Diabetes, Cytochrome P-450 SubstratesSynonyms: 1-(3-azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea, 1-(hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)ureaDiazoxide
go.drugbank.com/drugs/DB01119ApprovedInvestigational[A190372] When administered intravenously, diazoxide can be used to treat hypertensive emergencies;[L44622] however, this specific form of diazoxide is no longer available in the US. … [A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity.
Categories: Arteriolar Smooth Muscle, Agents Acting On, Cytochrome P-450 SubstratesSynonyms: 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide