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Lemborexant
go.drugbank.com/drugs/DB11951ApprovedInvestigational[L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits, but rather an inability to … [A189006] This novel mechanism of action offers potential advantages over classic hypnotic agents, including a more favorable adverse effect profile and potentially greater efficacy, and may signal the
Categories: Orexin Receptor Antagonists, P-glycoprotein substratesHormone Receptor Positive Breast Carcinoma
go.drugbank.com/conditions/DBCOND0119681Drugs: OlaparibSynonyms: Hormone-receptor-positive Breast Cancer, Hormone Receptor-Positive Breast CarcinomaMeradimate
go.drugbank.com/drugs/DB11096ApprovedMeradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products.[L1113, L2748]
Mixtures: Pro-Tect Sunscreen for Professionals, Pro-tect Sunscreen for ProfessionalsTrametinib
go.drugbank.com/drugs/DB08911ApprovedInvestigational[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. … Originally developed by Japan Tobacco, trametinib was initially investigated for treating inflammation, but further studies for this indication were not pursued.[A258298]
Categories: MAP Kinase, antagonists & inhibitors, MAP Kinase Kinase 1, antagonists & inhibitorsRosiglitazone
go.drugbank.com/drugs/DB00412ApprovedInvestigationalRecent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. … Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs.
Categories: Peroxisome Proliferator Receptor gamma Agonist, Peroxisome Proliferator-activated Receptor ActivitySynonyms: (±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedioneL-Glutamine
go.drugbank.com/drugs/DB00130ApprovedInvestigationalNutraceuticalIt is the principal carrier of nitrogen in the body and is an important energy source for many cells. … An oral formulation of L-glutamine was approved by the FDA in July 2017 for use in sickle cell disease [L892]. This oral formulation is marketed under the tradename Endari by Emmaus Medical.
Alprazolam
go.drugbank.com/drugs/DB00404ApprovedIllicitInvestigational[A18125] Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death. … Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMagnesium carbonate
go.drugbank.com/drugs/DB09481ApprovedMagnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label].
Mixtures: Cal Mag Tab, Mag/cal 1:1 Capsules W Vitamin DCategories: Drugs for Constipation, Drugs for Acid Related DisordersPioglitazone
go.drugbank.com/drugs/DB01132ApprovedInvestigational[A19759] Thiazolidinediones, including pioglitazone, have fallen out of favor in recent years due to the presence of multiple adverse effects and warnings regarding their use (e.g. congestive heart … Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.
Mixtures: INCRESINA PCategories: Peroxisome Proliferator Receptor gamma Agonist, Peroxisome Proliferator-activated Receptor ActivityZinc chloride
go.drugbank.com/drugs/DB14533ApprovedZinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc levels and prevent deficiency syndromes.
Mixtures: Orajel 4X Medicated PM For Toothache and Gum, PM Toothache ReliefCategories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use