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Melphalan flufenamide

Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan]. … [A230123] The increased potency makes melphalan flufenamide a treatment option for patients with relapsed or refractory multiple myeloma who have attempted at least 4 lines of therapy already.

Lactitol

Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. … [A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.[L11803]

Remibrutinib

[L54101] Bruton's tyrosine kinase plays a role in B cell receptor and Fc receptor signalling, releasing histamine and pro-inflammatory mediators. … Remibrutinib is a selective Bruton's tyrosine kinase inhibitor. The FDA approved remibrutinib on September 30, 2025 as the only oral, targeted treatment for chronic spontaneous urticaria.

Cetuximab

[A228083] EGFR has been implicated in various types of cancer, as it is often overexpressed in malignant cells [A227973] and EGFR overexpression has been linked to more advanced disease and poor prognosis … [A227973] EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it is responsible for regulating epithelial tissue development and homeostasis.

Methyltestosterone

A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. … Methyltestosterone is a schedule III drug in the US.

Clesrovimab

Clesrovimab is a fully human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody targeted against the extracellular domain of the respiratory syncytial virus (RSV) fusion (F) protein. … [A273953,A273978] Clesrovimab-cfor was approved by the US FDA in June 2025 for use in infants prior to or during their first RSV season.[L53228,L53233]

Phentermine

[A174367] Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. … Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.

Bromhexine

Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. … [A233240] Recently, bromhexine and its metabolite [ambroxol] have garnered interest for the potential prevention and treatment of COVID-19 due to their interactions with cell receptors in the lungs.

L-arginine

Manidipine

It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages. … Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.