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Novobiocin
go.drugbank.com/drugs/DB01051ApprovedInvestigationalVet approvedWithdrawnNovobiocin is an antibiotic compound derived from _Streptomyces niveus_. It has a chemical structure similar to coumarin. … Martindale The Extra Pharmacopoeia, 30th ed, p189) Novobiocin sodium, a salt form of novobiocin, was initially approved in September 1964 and was indicated for the treatment of serious infections due
Synonyms: N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-β-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamideDordaviprone
go.drugbank.com/drugs/DB14844ApprovedInvestigational[A274391] Dordaviprone has several modes of action, including the activation of mitochondrial caseinolytic protease P (ClpP), antagonism of the dopamine D2 receptor,[L53833] activation of Activating Transcription … [L53838] It is used to treat patients with diffuse midline glioma harboring an H3 K27M mutation.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2B6 InducersPromazine
go.drugbank.com/drugs/DB00420ApprovedVet approvedWithdrawnIt is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 SubstratesPergolide
go.drugbank.com/drugs/DB01186ApprovedVet approvedWithdrawnIt is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsCerebrotendinous Xanthomatosis (CTX)
go.drugbank.com/conditions/DBCOND0058089Drugs: Chenodeoxycholic acidSynonyms: Van Bogaert-Scherer-Epstein disease, Van Bogaert-Scherer-Epstein syndromeDanaparoid
go.drugbank.com/drugs/DB06754ApprovedWithdrawnWhile it was initially approved by the FDA as Orgaran™, danaparoid was withdrawn by Organon International on August 14, 2002, due to a shortage in drug substance by the manufacturer. … Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans [A32565].
Capecitabine
go.drugbank.com/drugs/DB01101ApprovedInvestigationalCapecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers.
Synonyms: pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate, Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InhibitorsDepemokimab
go.drugbank.com/drugs/DB18846ApprovedInvestigational[A275338] Approved by the FDA on December 16, 2025, depemokimab is indicated as an add-on maintenance treatment for severe asthma characterized by an eosinophilic phenotype in adult and paediatric patients
D-alpha-Tocopherol acetate
go.drugbank.com/drugs/DB14002ApprovedNutraceuticalVet approved, males = 6 mg (9 IU) females = 6 mg (9 IU) in ages 1-3 years, males = 7 mg (10.4 IU) females = 7 mg (10.4 IU) in ages 4-8 years, males = 11 mg (16.4 IU) females = 11 mg (16.4 IU) in ages 9-13 years, males … = 15 mg (22.4 IU) females = 15 mg (22.4 IU) pregnancy = 15 mg (22.4 IU) lactation = 19 mg (28.4 IU) in ages 14+ years [L2120].
Synonyms: Vitamin E acetate, D-, D-alpha tocoferil acetateMixtures: Kamu Jay Multi Complex Tab, Coen.q10w.vit.c and E Beta-car.se Cu Zn MnAnifrolumab
go.drugbank.com/drugs/DB11976ApprovedInvestigationalmonoclonal antibodies (anifrolumab, [rontalizumab], and [sifalimumab]) that target the type 1 interferon pathway entered clinical trials as potential treatments for systemic lupus erythematosus, but so far