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Displaying results 1291 - 1300 of 5758 in total
  1. Drug

    Tenofovir alafenamide

    go.drugbank.com/drugs/DB09299
    ApprovedInvestigational

    Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on te...

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substrates
  2. Drug

    Ganaxolone

    go.drugbank.com/drugs/DB05087
    ApprovedInvestigational

    Ganaxolone is the 3β-methylated synthetic analog of allopregnanolone, a metabolite of progesterone. Ganaxolone belongs to a class of compounds referred to as neurosteroids. Endogenous neurosteroids, which comprise certain metabolites of ...

    Categories: Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator, Cytochrome P-450 Substrates
  3. Drug

    Pesampator

    go.drugbank.com/drugs/DB11843
    Investigational

    PF-04958242 has been used in trials studying the basic science and treatment of Schizophrenia and Hearing Loss, Sensorineural.

  4. Drug

    Tianeptine

    go.drugbank.com/drugs/DB09289
    Investigational

    Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in the treatment of irritable bowel syndrome (IBS) . Structurally, it is classified as a tricyclic antidepressant (TCA), however, it p...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  5. Drug

    Dronedarone

    go.drugbank.com/drugs/DB04855
    ApprovedInvestigational

    Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primaril...

    Synonyms: N-(2-butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide, N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamideCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  6. Drug

    Clidinium

    go.drugbank.com/drugs/DB00771
    Approved

    Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylc...

    Synonyms: N-methyl quinuclidinyl benzilateMixtures: Nu-chlorax Capsules USP
  7. Drug

    NLX-P101

    go.drugbank.com/drugs/DB05924
    Experimental

    The gene is glutamic acid decarboxylase (GAD), whose product synthesizes the major inhibitory neurotransmitter in the brain, (gamma)-aminobutyric acid (GABA), and targets the subthalamic nucleus (STN),

  8. Drug

    Potassium carbonate

    go.drugbank.com/drugs/DB13977
    Approved

    Potassium carbonate (K2CO3) is a white salt, soluble in water (insoluble in ethanol) which forms a strongly alkaline solution. It can be made as the product of potassium hydroxide's absorbent reaction with carbon dioxide. It presents a l...

    Mixtures: Vit C W Calc-mag and Potass Powder
  9. Target

    Deacylase AADAC

    go.drugbank.com/bio_entities/BE0010087
    EnzymeHumans

    Catalyzes the hydrolysis of ester and amide bonds and is largely involved in prodrugs activation, xenobiotic detoxification or toxicity, and, in some contexts, lipid and indole metabolism (PubMed:17936933, PubMed:18034159, PubMed:1933937...

    Synonyms: DAC
  10. Drug

    Medrysone

    go.drugbank.com/drugs/DB00253
    Approved

    Medrysone is a corticosteroid used in ophthalmology.

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates