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Sparfloxacin
go.drugbank.com/drugs/DB01208ApprovedWithdrawnSparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. … DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Nirogacestat
go.drugbank.com/drugs/DB12005ApprovedInvestigational[A262556] Interaction between the notch receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling … Desmoid tumors are typically characterized by aberrant activation in Notch signaling.
Eslicarbazepine acetate
go.drugbank.com/drugs/DB09119ApprovedInvestigationalvoltage-gated sodium channels, thus preventing their return to the activated state during which seizure activity can occur. … Eslicarbazepine's mechanism of action is not well understood, but it is known that it does exert anticonvulsant activity by inhibiting repeated neuronal firing and stabilizing the inactivated state of
Bortezomib
go.drugbank.com/drugs/DB00188ApprovedInvestigational[A204083] In May 2003, bortezomib became the first anticancer proteasome inhibitor that was approved by the FDA under the trade name VELCADE.
Cupric oxide
go.drugbank.com/drugs/DB11134ApprovedCupric oxide, or copper (II) oxide, is an inorganic compound with the chemical formula CuO.
Mixtures: Natalvirt Ca, Focalgin CAValsartan
go.drugbank.com/drugs/DB00177ApprovedInvestigationalValsartan also affects the renin-angiotensin aldosterone system (RAAS), which plays an important role in hemostasis and regulation of kidney, vascular, and cardiac functions. … ARBs have been shown to have a protective effect on the heart by improving cardiac function, reducing afterload, increasing cardiac output and preventing ventricular hypertrophy and remodelling.
Mixtures: VALSARTAN HCT MK 80 MG/12.5 MG COMPRIMIDOS RECUBIERTOS, EXFORGE® 10/320 COMPRIMIDOS CON CUBIERTA PELICULARCantharidin
go.drugbank.com/drugs/DB12328ApprovedInvestigational[A32892] Nevertheless, it gained its first FDA approval on Jul 21, 2023, under the brand name YCANTH™ by Verrica Pharmaceuticals for the treatment of molluscum contagiosum in adult and pediatric patients … Cantharidin is a naturally occurring odorless, colorless fatty substance of the terpenoid class that is produced as an oral fluid in the alimentary canal of the male blister beetle.
Scutellaria lateriflora
go.drugbank.com/drugs/DB14339ApprovedIt is not an approved drug.
Mixtures: Herbal Slumber Cap, Hops-valerian Combination CapLiothyronine
go.drugbank.com/drugs/DB00279ApprovedInvestigationalVet approved[T457] The exogenous liothyronine product was developed by King Pharmaceuticals and FDA approved in 1956.[L5578] … Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3.
Somatrem
go.drugbank.com/drugs/DB09098ApprovedWithdrawnDespite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent...