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Displaying results 1301 - 1310 of 10000 in total
  1. Target

    Low affinity immunoglobulin gamma Fc region receptor II-b

    go.drugbank.com/bio_entities/BE0002099
    TargetHumans

    Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. … Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor.

    Polypeptides: Low affinity immunoglobulin gamma Fc region receptor II-bSynonyms: IgG Fc receptor II-b
  2. Target

    Transient receptor potential cation channel subfamily V member 6

    go.drugbank.com/bio_entities/BE0005102
    TransporterTargetHumans

    Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ...

    Polypeptides: Transient receptor potential cation channel subfamily V member 6
  3. Drug

    Pioglitazone

    go.drugbank.com/drugs/DB01132
    ApprovedInvestigational

    [A19759] Thiazolidinediones, including pioglitazone, have fallen out of favor in recent years due to the presence of multiple adverse effects and warnings regarding their use (e.g. congestive heart … Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.

    Mixtures: INCRESINA P, PIONIX M 850Categories: Peroxisome Proliferator Receptor gamma Agonist, Peroxisome Proliferator-activated Receptor Activity
  4. Drug

    Eflornithine

    go.drugbank.com/drugs/DB06243
    ApprovedInvestigationalWithdrawn

    [A262839] In 1960 and 2000, the FDA approved eflornithine under the brand names ORNIDYL and VANIQUA for the treatment of African trypanosomiasis and hirsutism, respectively, but has since been discontinued … a 68% reduction in the risk of death were observed.

    Synonyms: 2-(difluoromethyl)ornithine, α-difluoromethylornithine
  5. Drug

    Midazolam

    go.drugbank.com/drugs/DB00683
    ApprovedIllicitInvestigational

    [F2977] This drug was initially approved by the US FDA in 1985, and has been approved for various indications since. … Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: N/a, DORMICUM ® AMPOLLAS 5 MG/5 ML
  6. Drug

    Isopropyl myristate

    go.drugbank.com/drugs/DB13966
    Approved

    Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer. … Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption.

    Synonyms: 1-Methylethyl tetradecanoate
  7. Drug

    Vismodegib

    go.drugbank.com/drugs/DB08828
    ApprovedInvestigational

    [A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry. … However, dysregulated or aberrant Hedgehog signaling has been associated with basal cell carcinoma pathogenesis.

    Synonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-Categories: Smoothened Receptor Antagonists, P-glycoprotein substrates
  8. Indication

    Carbamyl Phosphate Synthetase Deficiency

    go.drugbank.com/conditions/DBCOND0051997
    Drugs: Phenylbutyric acid
    Synonyms: CPS1-gene related carbamoyl-phosphate synthetase 1 deficiency
  9. Drug

    Levomenol

    go.drugbank.com/drugs/DB13153
    Approved

    Bisabolol, or more formally α-(−)-bisabolol or also known as levomenol, (-)-alpha-Bisabolol is found in fats and oils. (-)-alpha-Bisabolol is isolated from essential oil of Matricaria chamomilla (German

    Synonyms: α-(−)-bisabololMixtures: Intense Multi Ampoule Balm Vita C, NEWSTEM Rx IPL VITA C Energy Ampoule
  10. Drug

    Edaravone

    go.drugbank.com/drugs/DB12243
    ApprovedInvestigational

    Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties.[A254257] It has three tautomers. … [A19140] Edaravone works to scavenge reactive oxygen species, which have been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and cerebral ischemia.

    Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingSynonyms: 1-phenyl-3-methyl-5-oxo-2-pyrazoline, 3-methyl-1-phenyl-2-pyrazolin-5-one