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Cetalkonium
go.drugbank.com/drugs/DB11583ApprovedWithdrawn[A27143] It is a quaternary ammonium salt that acts as an antiseptic against a variety of bacteria and fungi. … Cetalkonium is a C16 alkyl benzalkonium chloride derivative with an amphipathic property which allows it to be used in different types of formulations.
Categories: Compounds used in a research, industrial, or household settingDiroximel fumarate
go.drugbank.com/drugs/DB14783ApprovedInvestigational[A187535] Diroximel fumarate is a new drug from the fumarate class formulated to treat various relapsing forms of MS. … Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life.
Silver
go.drugbank.com/drugs/DB12965ApprovedInvestigationalSilver (Ag) is a chemical element that belongs in the family of transition metals in the periodic table. It has a high electrical conductivity, thermal conductivity, and reflectivity. … Having critical roles in various applications inducing chemical and industrial fields, silver compounds have also been used in the field of medicine for centuries due to their broad-spectrum biological
Ergoloid mesylate
go.drugbank.com/drugs/DB01049ApprovedErgoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. … [T90] The derivatives of this fungus are identified to be about 350 different substances from which the components of the ergoloid mesylate mixture are composed of the dihydrogenated ergot alkaloid derivatives
Categories: Heterocyclic Compounds with 4 or More Rings, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeAvapritinib
go.drugbank.com/drugs/DB15233ApprovedInvestigationalAvapritinib, or BLU-285,[A189327] is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal … [A189339,L40363] It is one of the first medications available for the treatment of multidrug resistant cancers.[A189327] Avapritinib shares a similar mechanism with [ripretinib].
Lonafarnib
go.drugbank.com/drugs/DB06448ApprovedInvestigational[A224379, A224384, A224389, A224394, A224399] Mechanistically, HGPS is underpinned by a single heterozygous C-to-T mutation at position 1824 of the _LMNA_ gene, which results in the accumulation of an … aberrant farnesylated form of lamin A called progerin in the inner nuclear membrane.
Diphenoxylate
go.drugbank.com/drugs/DB01081ApprovedIllicitInvestigationalIt has little or no analgesic activity. … A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine.
Mixtures: PHARMANIAGA DIPHENOXYLATE A TABLETCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeMethylchloroisothiazolinone
go.drugbank.com/drugs/DB14197ApprovedIt is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. … Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties.
Categories: Compounds used in a research, industrial, or household settingSafinamide
go.drugbank.com/drugs/DB06654ApprovedInvestigationalSafinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeLiraglutide
go.drugbank.com/drugs/DB06655ApprovedInvestigational[A6932] Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer on the remaining lysine residue at position 26 of the peptide precursor. … Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.