Diphenoxylate is an antidiarrheal medication used with atropine to manage diarrhea. At high doses, it acts like morphine.
- Mechanism
- Curator reviewed
Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa.
- Primary indication
- For as adjunctive therapy in the management of diarrheaCurator reviewed · 1 structured indication
- Formula / weight
- C30H32N2O2 · 452.5873 g/mol (avg)
- First approval
- Canada, 2003 · United States, 1960
- Code names
- DEA No. 9170 · IDS-ND-016 · R-1132
- Brand names
Resolves to
HYPPXZBJBPSRLK-UHFFFAOYSA-NSMILESCCOC(=O)C1(CCN(CCC(C#N)(C2=CC=CC=C2)C2=CC=CC=C2)CC1)C1=CC=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Diphenoxylate, and which of those have an active Phase 3 trial?
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