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Mepolizumab
go.drugbank.com/drugs/DB06612ApprovedInvestigationalThe pathogenesis of eosinophilia is complex, but IL-5 is recognized as a key cytokine involved in the differentiation, recruitment, activation, and prolonged survival of eosinophils in peripheral tissue … Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm<sup>3</sup> or more) is associated with a spectrum
Products: NUCALA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML, Nucala 100mg/ml Solution for Injection in pre-filled pen (Autoinjector)Histamine
go.drugbank.com/drugs/DB05381ApprovedInvestigationalIt is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. … A depressor amine derived by enzymatic decarboxylation of histidine.
Mixtures: MIKES Ponos Pain Relief Cream Roll-OnProducts: Mancore Muscle Mend Roll-ON Pain Reliever4-(Isopropylamino)diphenylamine
go.drugbank.com/drugs/DB14195Approved4-(Isopropylamino)diphenylamine, also known as IPPD, is a chemical compound commonly used as an antiozonant in rubbers, particularly those used for tires. It is also a known allergen. … Sensitivity to this compound may be identified with a clinical patch test.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Nonox ZA, N-Fenyl-N'-isopropyl-p-fenylendiaminSugemalimab
go.drugbank.com/drugs/DB16641ApprovedInvestigational[L32868] Sugemalimab was under investigation in the clinical trial NCT03802591 (A Study of CS1001 in Subjects With Gastric Adenocarcinoma or Gastro-esophageal Junction Adenocarcinoma). … Sugemalimab is a fully human, full-length anti-programmed death-ligand 1 (PD-L1) monoclonal antibody (of the IgG4 isotype) discovered by CStone Pharmaceuticals.
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsViloxazine
go.drugbank.com/drugs/DB09185ApprovedInvestigationalWithdrawnViloxazine is a selective norepinephrine reuptake inhibitor.[L41685] For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. … In the US, viloxazine was assigned an orphan drug designation in 1984 under the brand name CATATROL: while this product was intended to treat cataplexy and narcolepsy, the drug was never approved for these
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Monoamine Oxidase A InhibitorsOmbitasvir
go.drugbank.com/drugs/DB09296ApprovedInvestigationalIn a joint recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) recommend Ombitasvir as a first line … therapy option when used in combination with other antivirals for genotypes 1a, 1b, and 4 [L852].
Stannous fluoride
go.drugbank.com/drugs/DB11092ApprovedInvestigationalStannous Fluoride, or Tn(II) Fluoride, is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity. … It is an FDA-approved over-the-counter product.
Categories: Compounds used in a research, industrial, or household settingProducts: H E B Restore and Defend, Pro-Den RxEdaravone
go.drugbank.com/drugs/DB12243ApprovedInvestigationalEdaravone is a free radical scavenger and neuroprotective agent with antioxidant properties.[A254257] It has three tautomers. … by the Committee for Medicinal Products for Human Use (CHMP) for a long-term study demonstrating the long-term efficacy and safety of edaravone.
Categories: Compounds used in a research, industrial, or household settingElvitegravir
go.drugbank.com/drugs/DB09101ApprovedInvestigationalAlthough available as a single dose tablet, elvitegravir must be used in combination with an HIV protease inhibitor coadministered with ritonavir and another antiretroviral drug. … Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.
Categories: Antivirals used in combination for the treatment of HIV infectionsFluoroestradiol F-18
go.drugbank.com/drugs/DB15690ApprovedInvestigational[L14096] The ability to image ER-positive tumors _in vivo_ is advantageous in that, while helping to visualize tumor progression/regression, it may also be used to assess for heterogeneity in ER expression … across metastases (i.e. to identify sites that no longer express ER) without the need for multiple biopsies.