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Nilutamide
go.drugbank.com/drugs/DB00665ApprovedInvestigationalNilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. … Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors).
Tibolone
go.drugbank.com/drugs/DB09070ApprovedInvestigationalIn June 2006, Organon Pharmaceuticals announced the receipt of a Not Approvable Letter from the U.S. … Tibolone is a synthetic steroid hormone drug, which is mainly non-selective in its binding profile, acting as an agonist primarily at estrogen receptors (ER), with a preference for ER alpha [L1874].
Categories: Sex Hormones and Modulators of the Genital SystemClodronic acid
go.drugbank.com/drugs/DB00720ApprovedInvestigationalVet approved[A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. … Clodronic acid is a first generation bisphosphonate similar to [etidronic acid] and [tiludronic acid].
Categories: Drugs for Treatment of Bone DiseasesRifamycin
go.drugbank.com/drugs/DB11753ApprovedInvestigationalWithdrawn[L4800] This drug was also sent for review to the EMA in 2015 by Dr. Falk Pharma Gmbh and it was granted a waiver for the tested conditions.[L4801] … The parent compound of rifamycin was rifamycin B which was originally obtained as a main product in the presence of diethylbarburitic acid.
Categories: Drugs for Treatment of Tuberculosis, Heterocyclic Compounds with 4 or More RingsGolimumab
go.drugbank.com/drugs/DB06674ApprovedInvestigationalulcerative colitis (UC) who require chronic steroids or have experienced intolerance or only a partial response to previous medications. … Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with moderate to severe active rheumatoid arthritis (RA), (ii) alone or as an adjunct to methotrexate
Kappadione
go.drugbank.com/drugs/DB09332ApprovedStudies involving the active metabolite of this formulation, menadione, showed oocyte toxicity in a study of mice [L1544]. … It has been found to have carcinogenic potential in mammalian cells as well as cytotoxic properties [L1544].
Dobutamine
go.drugbank.com/drugs/DB00841ApprovedInvestigationalA beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Synonyms: DL-dobutamineCategories: Compounds used in a research, industrial, or household settingChorionic Gonadotropin (Human)
go.drugbank.com/drugs/DB09126ApprovedInvestigationalVet approvedHCG is composed of an alpha and a beta sub-unit. … As a drug product, chorionic gonadotropin is a highly purified pyrogen-free preparation obtained from the urine of pregnant females.
Categories: Sex Hormones and Modulators of the Genital SystemProducts: Apl Inj 1000 Iu/ml, PREGNYL INJECTION 5000 IUIoxitalamic acid
go.drugbank.com/drugs/DB13444ApprovedWithdrawnIoxitalamate is an ionic iodinated contrast medium.[A27209] It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg. … [A33006] Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995.
Categories: Compounds used in a research, industrial, or household setting, Diagnostic Uses of ChemicalsBenralizumab
go.drugbank.com/drugs/DB12023ApprovedInvestigational[A31294] It inhibits the binding of IL-5 as well as the hetero-oligomerization of the alpha and beta subunits of the IL-5R, thus blocking signal transduction. … Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils