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Bedaquiline
go.drugbank.com/drugs/DB08903ApprovedInvestigational[A261856,A261861] It is the first drug that was approved in the last 40 years by the FDA for TB unresponsive to current treatments on the market. … [L48506] Although the current standard of TB treatment of anti-TB drugs for 2 months, including 2 key drugs [isoniazid] and [rifampin], is highly effective, the emergence of multidrug-resistant TB (MDR-TB
Hydromorphone
go.drugbank.com/drugs/DB00327ApprovedIllicitInvestigationalStructurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. … Due to these modifications, it presents a very high potency and comparable side effect profile to the parent compound.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeTianeptine
go.drugbank.com/drugs/DB09289InvestigationalTianeptine was discovered and patented by The French Society of Medical Research in the 1960s [L2946]. … Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in the treatment of irritable bowel syndrome (IBS) [A31983].
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeErgoloid mesylate
go.drugbank.com/drugs/DB01049Approved[T90] The derivatives of this fungus are identified to be about 350 different substances from which the components of the ergoloid mesylate mixture are composed of the dihydrogenated ergot alkaloid derivatives … [L2640] To know more about the individual components of the ergoloid mixture, please visit [DB11275], [DB11274], [DB11273] and [DB13345].
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Ergot-derivative Dopamine Receptor AgonistsInaxaplin
go.drugbank.com/drugs/DB21521InvestigationalInaxaplin is under investigation in clinical trial NCT06794996 (Phase 2b Open-label Study of Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease).
Apalutamide
go.drugbank.com/drugs/DB11901ApprovedInvestigationalApalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements [A31846] … In a phase-2 multicenter open-label study, 89% of patients with non-metastatic, castration-resistant prostate cancer had ≥50% PSA decline at week 12 of apalutamide treatment [A31846].
Categories: Androgen Receptor InhibitorsBupivacaine
go.drugbank.com/drugs/DB00297ApprovedInvestigationalBupivacaine is a widely used local anesthetic agent.
Mixtures: Marcaine E, Marcaine EProducts: BUPIVACAINA BONISCONTRO E GAZZONEDextran
go.drugbank.com/drugs/DB09255ApprovedInvestigationalVet approvedThe main chain of glucose has short branches at frequent intervals which are probably joined by 1:3 and 1:4 glucoside links. The chains can be composed of about 200,000 glucose units. … When labelled with technetium Tc99m, dextran 75 is intravenously administered as an imaging agent to detect and diagnose conditions in the vascular compartment such as pericardial effusion or ventricular
Mixtures: BIOFLEKS %10 DEKSTRAN-40 %0,9 IZOTONIK SODYUM KLORUR ÇÖZELTİSİ (PVC TORBA) 500 ML VE SETLIProducts: DEKSTRAN 40 İE (SETLİ), DEKSTRAN 70 İE (SETLİ)Arginine
go.drugbank.com/drugs/DB00125ApprovedInvestigationalNutraceuticalAn essential amino acid that is physiologically active in the L-form.
Mixtures: Clinimix E, Clinimix EIsoniazid
go.drugbank.com/drugs/DB00951ApprovedInvestigationalIt remains the treatment of choice for tuberculosis.
Mixtures: TB VIT 6, PRO TB 4Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome