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Phentolamine
go.drugbank.com/drugs/DB00692ApprovedInvestigationalWhile initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral
Synonyms: 2-(N-(m-hydroxyphenyl)-p-toluidinomethyl)imidazolineProducts: Rogitine 5mg/vialDoxorubicin
go.drugbank.com/drugs/DB00997ApprovedInvestigationalDoxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970. Although they both have aglyconic and sugar moieties, doxor...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: U. DOXORUBICIN HCL FOR INJECTION 50 mg/vial, U. DOXORUBICIN HCL FOR INJECTION 10 mg/vialPoractant alfa
go.drugbank.com/drugs/DB09113ApprovedInvestigationalPoractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada. It is used to treat Respiratory Distress Syndrome (RDS) in premature infants with an endogenous pulmonary surfactant deficiency. Poractant alf...
Products: CUROSURF VIAL 1.5ML, CUROSURF VIAL 3.0MLPolymyxin B
go.drugbank.com/drugs/DB00781ApprovedInvestigationalVet approvedPolymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxi...
Mixtures: OTEK-P EAR DROPS, PS-2261 Triple Antibiotic, 0.5gProducts: POLIMIXINA B 500.000 UI/VIAL, POLIMIXINA B SULFATO PARA INYECCIÓN 500.000 UI/VIALLurbinectedin
go.drugbank.com/drugs/DB12674ApprovedInvestigationalLurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative...
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsProducts: ZEPZELCA POWDER FOR SOLUTION FOR INFUSION 4MG/VIALEdetate disodium anhydrous
go.drugbank.com/drugs/DB14600ApprovedInvestigationalVet approvedEdetate disodium anhydrous is a polyvalent chelating agent used to treat hypercalcemia and digitalis toxicity associated ventricular arrhythmias.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: EDTA INJECTION 150MG/ML (VIAL)Gemcitabine
go.drugbank.com/drugs/DB00441ApprovedInvestigationalGemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers. Gemcitabine is a cytidine analog with two fluorin...
Categories: P-glycoprotein substrates, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: GEMCITABINA DR. REDDY'S, Gemzar (1gm/vial)Amantadine
go.drugbank.com/drugs/DB00915ApprovedInvestigationalAn antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in move...
Mixtures: FROSDEM-PInternational brands: PK-MerzOxaliplatin
go.drugbank.com/drugs/DB00526ApprovedInvestigational[A797] Due to this chemical moiety, oxaliplatin readily undergoes non-enzymatic biotransformation, thus complicating oxaliplatin's pharmacokinetics. … [A260396] However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic
Products: HOXALIRA®50 MG/VIAL, HOXALIRA® 100 MG/ VIALInsulin glargine
go.drugbank.com/drugs/DB00047ApprovedInvestigationalThe resulting protein is soluble at pH 4 and forms microprecipitates at physiological pH 7.4 allowing for the slow release of small amounts of insulin glargine, giving the drug a long duration of action … Insulin glargine is also available as the biosimilar, or "follow-on" product, Basaglar in the US and as Abasaglar in the EU.
Mixtures: SOLİQUA SOLOSTAR 100 U/ML + 33 MCG/ML SC ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 5 KALEM, SOLİQUA SOLOSTAR 100 U/ML + 50 MCG/ML SC ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 5 KALEMCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme Inducers