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Displaying results 1411 - 1420 of 10000 in total
  1. Target

    Transient receptor potential cation channel subfamily V member 6

    go.drugbank.com/bio_entities/BE0005102
    TransporterTargetHumans

    Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ...

    Polypeptides: Transient receptor potential cation channel subfamily V member 6
  2. Drug

    Antihemophilic factor human

    go.drugbank.com/drugs/DB13192
    ApprovedInvestigational

    fibrinogen to fibrin, the fibrous protein that creates the scaffold of the clot. … Endogenous Factor VIII is essential to the clotting process in the body due to its involvement in the clotting cascade where it is responsible for acting as a co-factor to Factor IX.

    Mixtures: ENJEKSİYON/İNFÜZYON İÇİN TOZ VE ÇÖZÜCÜ, ENJEKSİYON/İNFÜZYON İÇİN TOZ VE ÇÖZÜCÜProducts: HAEMOCTİN SDH 500 IU/10 ML IV ENJEKSİYONLUK TOZ VE ÇÖZÜCÜ, BERIATE 500 IU IV ENJEKSİYONLUK/İNFÜZYONLUK LİYOFİLİZE TOZ VE ÇÖZÜCÜSÜ, 1 ADET
  3. Drug

    Remtolumab

    go.drugbank.com/drugs/DB15128
    Investigational

    Remtolumab is under investigation in clinical trial NCT02433340 (Phase 2, Multicenter, Open-Label Extension (OLE) Study With ABT-122 in Rheumatoid Arthritis Subjects Who Have Completed the Preceding M12

  4. Drug

    Pracinostat

    go.drugbank.com/drugs/DB05223
    Investigational

    Pracinostat is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in clinical trials, allowing oral dosing.

  5. Drug

    AZD2389

    go.drugbank.com/drugs/DB22104
    Investigational

    NCT06973005: A Study to Investigate How Multiple Oral Doses of AZD2389 Affect the Pharmacokinetics of Midazolam, Caffeine, and Bupropion in Healthy Participants).

  6. Drug

    Ramipril

    go.drugbank.com/drugs/DB00178
    ApprovedInvestigational

    Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. … Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).

    Mixtures: RAMIPRIL E IDROCLOROTIAZIDE GIT, RAMIPRIL E IDROCLOROTIAZIDE GITCategories: Agents Acting on the Renin-Angiotensin System
  7. Drug

    Fosinopril

    go.drugbank.com/drugs/DB00492
    ApprovedInvestigational

    Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals … It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).

    Mixtures: FOSINOPRIL E IDROCLOROTIAZIDE AUROBINDO, FOSINOPRIL E IDROCLOROTIAZIDE AUROBINDOCategories: Agents Acting on the Renin-Angiotensin System
  8. Drug

    Drospirenone

    go.drugbank.com/drugs/DB01395
    ApprovedInvestigational

    [A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding … Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.

    Mixtures: ACTIVA DE +TABLETAS RECUBIERTAS, ETINILESTRADIOLO E DROSPIRENONE DOCCategories: Sex Hormones and Modulators of the Genital System, Mineralocorticoid Receptor Antagonists
  9. Drug

    Calcium acetate

    go.drugbank.com/drugs/DB00258
    Approved

    The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. … The anhydrous form is very hygroscopic, therefore the monohydrate is the common form.

    Mixtures: ACETATO DE ALUMINIO, ACETATO DE ALUMINIO POLVO
  10. Drug

    Trandolapril

    go.drugbank.com/drugs/DB00519
    ApprovedInvestigational

    Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … It is metabolized to its biologically active diacid form, trandolaprilat, in the liver.

    Categories: Agents Acting on the Renin-Angiotensin System