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Vigabatrin
go.drugbank.com/drugs/DB01080ApprovedInvestigationalAlthough administered as a racemic mixture, only the S(+) enantiomer is pharmacologically active. … [A202124] Its use is now generally reserved for patients who have failed alternative therapies, and its US approval by the FDA in 2009 mandated the creation of a drug registry to monitor patients for visual
Categories: Cytochrome P-450 CYP2C9 Inducers, Cytochrome P-450 Enzyme InducersProducts: SABRIL 500 MG 50 SASE, SABRIL 500 MGSulfasalazine
go.drugbank.com/drugs/DB00795ApprovedInvestigational[A255582] Sulfasalazine fell out of favor as the drug of choice for RA due to poorly designed clinical trials in 1950 but regained interest from the clinical community in the late 1970. … It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).
Products: SAZOPIN TABLET 500 MG, ROSULFANT® 500 MGTrabectedin
go.drugbank.com/drugs/DB05109ApprovedInvestigationalTrabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. … Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically.
Categories: Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexProducts: YONDELIS 1 MG IV KONSANTRE INFUZYONLUK COZELTI ICIN TOZ, Trabectedin TEVA 0,25 mg Pulver für ein Konzentrat zur Herstellung einer InfusionslösungRaloxifene
go.drugbank.com/drugs/DB00481ApprovedInvestigationalHowever, it has a negligible effect on altering the development and progression of breast cancer itself. … [A4979,T28] Exhibiting tissue-specific effects distinct from [estradiol], raloxifene is the first of the benzothiophene group of antiestrogens to be labelled a SERM.
Categories: Cytochrome P-450 CYP2B6 Inhibitors, Cytochrome P-450 CYP2C8 InhibitorsProducts: EVISTA TABLET 60 mg, Evista Tablet 60 mgIsavuconazonium
go.drugbank.com/drugs/DB06636ApprovedInvestigationalIsovuconazonium has excellent oral bioavailability, predictable pharmacokinetics, and a good safety profile, making it a reasonable alternative to its few other competitors on the market. … Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesProducts: CRESEMBA® 200 MG POLVO LIOFILIZADO ESTERIL PARA RECONSTITUIRBezafibrate
go.drugbank.com/drugs/DB01393ApprovedInvestigationalAntilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsProducts: BEZAFIBRATO 200 MG, ZAFIBRAL TABLET 200 mgSulfinpyrazone
go.drugbank.com/drugs/DB01138ApprovedA uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesProducts: ยาเม็ดซัลฟิน 100 มิลลิกรัม, Sulfinpyrazone 100 TabBBV152
go.drugbank.com/drugs/DB15847Investigationalor a novel TLR7/8 agonist adsorbed gel. … The candidate, a whole virion inactivated SARS-CoV-2 vaccine, was developed from a well-known SARS-CoV-2 strain and a vero cell platform (CCL-81) with adjuncts of either aluminum hydroxide gel (Algel)
Synonyms: BBV-152Exemestane
go.drugbank.com/drugs/DB00990ApprovedInvestigationalExemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: EXEMESTAN AL 25 MG, EXEMESTAN 1A PHARMA 25MGLumiliximab
go.drugbank.com/drugs/DB06162InvestigationalLumiliximab is a chimeric monoclonal antibody which is used as an immunosuppressive drug. … It is a primatized anti-CD23 macaque/human chimeric antibody that inhibits the production of the IgE antibody, for the potential treatment of allergic conditions.
Synonyms: IMMUNOGLOBULIN G1, ANTI-(HUMAN IMMUNOGLOBULIN E RECEPTOR TYPE II) (HUMAN-MACACA IRUS MONOCLONAL IDEC-152 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MACACA IRUS MONOCLONAL IDEC-152 .KAPPA.-CHAIN, DIMER, IMMUNOGLOBULIN G1, ANTI-(HUMAN IMMUNOGLOBULIN E RECEPTOR TYPE II) (HUMAN-MACACA IRUS MONOCLONAL IDEC-152 .GAMMA.1-CHAIN), DISULPHIDE WITH HUMAN-MACACA IRUS MONOCLONAL IDEC-152 .KAPPA.-CHAIN, DIMER