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Ioversol
go.drugbank.com/drugs/DB09134ApprovedInvestigationalIoversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. … [L41780] Iodine has a high atomic density, which gives it the ability to attenuate X-rays.
Categories: Compounds used in a research, industrial, or household settingCabamiquine
go.drugbank.com/drugs/DB21477InvestigationalCabamiquine is under investigation in clinical trial NCT05974267 (Efficacy, Safety, and PK of M5717 in Combination With Pyronaridine as Chemoprevention in Adults and Adolescents With Asymptomatic Plasmodium … Cabamiquine is a small molecule drug.
Sulbactam
go.drugbank.com/drugs/DB09324ApprovedInvestigationalSulbactam is a beta (β)-lactamase inhibitor and a derivative of the basic penicillin nucleus. … [L50131] When given in combination with β-lactam antibiotics, sulbactam produces a synergistic effect as it blocks the enzyme responsible for drug resistance by hydrolyzing β-lactams.[A263296]
Mixtures: AUROPENNZ 1.5 G POLVO ESTERIL PARA RECONSTITUIR A SOLUCION INYECTABLE, UNASYN 1M/IV 3.0GProducts: B-LAKTAM 1 GR IM/IV ENJEKTABL TOZ ICEREN FLAKON, 5 ADET, B-LAKTAM 1 GR IM/IV ENJEKTABL TOZ ICEREN FLAKON, 100 ADETEnzalutamide
go.drugbank.com/drugs/DB08899ApprovedInvestigational[A252667] Second-generation such as enzalutamide is more efficacious due to a higher affinity to AR and no partial agonist activity compared to bicalutamide. … [A252667,A252642] Due to a favorable pharmacological profile, a phase 1 study of enzalutamide was initiated in July 2007.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesDifelikefalin
go.drugbank.com/drugs/DB11938ApprovedInvestigational[A237610] These revelations led to the study of KOR agonists as a potential treatment option in patients suffering from pruritic conditions. … [A237615,A237620] The clinical burden of uremic pruritus in this patient population is being increasingly recognized as contributing to a significant reduction in patient quality of life, poor outcomes
Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen
go.drugbank.com/drugs/DB16709Approved[L35505] It was developed as an alternative to autografting - the process by which a patient's own skin is harvested and grafted onto the burn site - which has the disadvantage of creating a new wound … Sheets containing this scaffold product are applied to the burn site and, as they contain metabolically active and viable cells, provide a variety of human growth factors and cytokines as well as extracellular
Ecallantide
go.drugbank.com/drugs/DB05311ApprovedBy reversibly binding to plasma kallikrein, ecallantide displays a rapid on-rate and a slow off-rate that results in high affinity inhibition in the picomolar range [L1458]. … Ecallantide is a potent and selective human plasma kallikrein inhibitor that is indicated for the symptomatic treatment of hereditary angioedema.
Levosalbutamol
go.drugbank.com/drugs/DB13139Approved[Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. … The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has adverse effects have led to the development of an enantiomerically pure (R)-salbutamol formulation known as levosalbutamol
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsChlormerodrin
go.drugbank.com/drugs/DB00534ApprovedWithdrawnChlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.
SF1126
go.drugbank.com/drugs/DB05210InvestigationalSF1126 is an integrin-targeted PI3 kinase inhibitor.