Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen is a viable, bioengineered, allogeneic, cellularized scaffold product applied to deep thermal burns to aid in healing. It was developed as an alternative to autografting - the process by which a patient's own skin is harvested and grafted onto the burn site - which has the disadvantage of creating a new wound...
- Mechanism
- Curator reviewed · 1 reference
Stratagraft consists of a murine collagen matrix with human keratinocytes and dermal fibroblasts embedded within. As these cells are viable and metabolically active, they secrete human growth factors and cytokines that help to heal the affected tissues. The Stratagraft cells are slowly replaced by the patient's own cells over time, which aids in wound closure and can help to eliminate or reduce the need for autologous skin grafting (i.e. autografting).
- Primary indication
- Stratagraft is an allogeneic cellularized scaffold product indicated for the treatment of adults with thermal burns containing intact dermal elements for which surgical intervention is clinically indicated (deep partial-thickness burns).Curator reviewed · 1 structured indication
- First approval
- United States, 2021
- Also known as
- allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen-dsat · Viable and metabolically active allogeneic human NIKS keratinocytes and human dermal fibroblasts cellularized layered scaffold
- Brand names
Resolves to
What you can answer from here — as of April 02, 2025
Which other approved drugs treat the same conditions as Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen, and which companies have late-stage candidates in those indications?
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