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Zucapsaicin
go.drugbank.com/drugs/DB09120ApprovedWithdrawnZucapsaicin has also been evaluated for the management of several conditions manifested by chronic nerve pain. … It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1, that reduces pain and improves articular functions.
Categories: Topical Products for Joint and Muscular PainGefurulimab
go.drugbank.com/drugs/DB18928InvestigationalGefurulimab is under investigation in clinical trial NCT05556096 (Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis).
Roflumilast
go.drugbank.com/drugs/DB01656ApprovedInvestigational[L46541] On December 15, 2023, the FDA approved a new topical foam formulation of roflumilast for the treatment of seborrheic dermatitis in patients aged 9 years and older.[L49281] … [A251385] PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme [L37564] expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells
Categories: Antipsoriatics for Topical Use, Drugs for Obstructive Airway DiseasesFormestane
go.drugbank.com/drugs/DB08905ApprovedWithdrawnIt is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes. … It is not US FDA approved, and the intramuscular injection form of formestane (Lentaron) which was approved in Europe has been withdrawn.
Sertaconazole
go.drugbank.com/drugs/DB01153ApprovedIt is available in topical formulations for the treatment of skin infections such as athlete's foot.
Categories: Antifungals for Topical Use, Antifungals for Dermatological UseFerric oxide
go.drugbank.com/drugs/DB11576ApprovedInvestigationalIt is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, and iron(II,III) oxide (Fe3O4) which naturally as magnetite. … Iron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3.
Mixtures: Aloe Vera CalamineCategories: Compounds used in a research, industrial, or household settingPhenazopyridine
go.drugbank.com/drugs/DB01438ApprovedInvestigationalPhenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during … Ingestion of phenazopyridine is found to change the appearance of the urine by imparting an orange or red color, as it is considered an azo dye.[L7829]
Mixtures: All-In-One UTI Emergency Kit, All-In-One UTI Emergency KitNaldemedine
go.drugbank.com/drugs/DB11691ApprovedInvestigationalNaldemedine was approved in 2017 in both the US and Japan for the treatment of Opioid-induced Constipation. … It is a modified form of [DB00704] to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier.
Categories: Drugs for Constipation, Heterocyclic Compounds with 4 or More RingsOritavancin
go.drugbank.com/drugs/DB04911ApprovedInvestigationalOritavancin is a glycopeptide antibiotic used for the treatment of skin infections. It was developed by The Medicines Company (acquired by Novartis). … Marketed by Melinta Therapeutics, Kimyrsa offers effective and time-efficient treatment for skin and skin structure infections.[L32629]
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseSelegiline
go.drugbank.com/drugs/DB01037ApprovedInvestigationalVet approvedIt may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability.
Categories: Antidepressive Agents Indicated for Depression, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates