Sertaconazole is a topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients. Sertaconazole nitrate is an antifungal medication of the imidazole class.
- Mechanism
- Curator reviewed
Sertaconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
- Primary indication
- For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.Curator reviewed · 3 structured indications
- Formula / weight
- C20H15Cl3N2OS · 437.77 g/mol (avg)
- First approval
- United States, 2003
- Code names
- FI-7045
- Brand names
Resolves to
JLGKQTAYUIMGRK-UHFFFAOYSA-NSMILESClC1=CC(Cl)=C(C=C1)C(CN1C=CN=C1)OCC1=CSC2=C1C=CC=C2ClWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Sertaconazole, and which of those have an active Phase 3 trial?
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