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Ledipasvir
go.drugbank.com/drugs/DB09027ApprovedApproved in October 2014 by the FDA, Harvoni is indicated for the treatment of HCV genotypes 1, 4, 5, and 6 with or without [ribavirin] depending on the level of liver damage or cirrhosis [FDA Label]. … SVR and eradication of HCV infection is associated with significant long-term health benefits including reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma
Categories: Antivirals for treatment of HCV infectionsPropylene glycol
go.drugbank.com/drugs/DB01839ApprovedInvestigationalA clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
Mixtures: Dg Lubricant Eye Drops, DG Lubricant Eye DropsCategories: Compounds used in a research, industrial, or household settingTestosterone enanthate
go.drugbank.com/drugs/DB13944ApprovedInvestigational[A31615] This testosterone derivative was first approved on December 24, 1953.[L8941] In 2017, about 6.5 million retail prescriptions for testosterone therapy were filled [L4659]. … Testosterone enanthate is an esterified variant of testosterone that comes as an injectable compound with a slow-release rate.
Cilazapril
go.drugbank.com/drugs/DB01340ApprovedInvestigationalCilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure. It belongs to the angiotensin-converting enzyme inhibitors (ACE inhibitors) class of drugs. … It is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States.
Categories: Agents Acting on the Renin-Angiotensin SystemTazobactam
go.drugbank.com/drugs/DB01606ApprovedInvestigationalIt is combined with [Piperacillin] and [Ceftolozane] for the treatment of a variety of bacterial infections. … Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms.
Mixtures: Zosyn in Galaxy Containers, Zosyn in Galaxy ContainersPropiomazine
go.drugbank.com/drugs/DB00777ApprovedFuture uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. … Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia.
Categories: Dopamine D2 Receptor AntagonistsBenznidazole
go.drugbank.com/drugs/DB11989ApprovedInvestigationalBenznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. … [L939] It is the first treatment made available in the United States for Chagas disease.
Inotuzumab ozogamicin
go.drugbank.com/drugs/DB05889ApprovedInvestigational[A20352] The antibody portion of the drug binds to CD22 receptors expressed on leukemic B cells and intracellularly releases N-acetyl-gamma-calicheamicin dimethylhydrazide, which produces cytotoxic effects … [A20352] Inotuzumab ozogamicin was first approved by the European Commission in June 2017 for the treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
Categories: CD22 (Clusters of Differentiation 22) inhibitorsOrphenadrine
go.drugbank.com/drugs/DB01173ApprovedInvestigationalA muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Mixtures: MYOGESIC-O, MYOGESIC-ORCategories: Metabolic Side Effects of Drugs and SubstancesSutilain
go.drugbank.com/drugs/DB09379ApprovedWithdrawnOne gram of sutilain powder contains 250,000 casein units of proteolytic activity.[T169] Sutilain was developed by Abbott and FDA approved on June 12, 1969. It is currently discontinued.[L2368] … Sutilain is a member of the keratase family which includes agents such as papain. It is able to dissolve the intercellular matrix which helps with desquamation.